1-s2.0-S0040402012016389-main (1)

A practical isocyanide-based multicomponent synthesis of polysubstituted cyclopentenes

Akin Sa g ?rli a ,Yas ?ar D €u

r €u st a ,Benson Kariuki b ,David W.Knight b ,*a Department of Chemistry,Abant _Izzet Baysal University,TR-14280Bolu,Turkey

b

School of Chemistry,Cardiff University,Main College,Park Place,Cardiff CF103AT,UK

a r t i c l e i n f o

Article history:

Received 11July 2012

Received in revised form 3October 2012Accepted 22October 2012

Available online 30October 2012Keywords:

Multicomponent Cyclopentene

Ylidenemalononitriles Isocyanide b -Nitrostyrene

a b s t r a c t

A number of polysubstituted cyclopentenes have been obtained by a multicomponent catalyst-free reaction using a combination of b -nitrostyrene,benzylidenemalononitriles and 2-morpholinoethyl isocyanide.

ó2012Elsevier Ltd.All rights reserved.

1.Introduction

Multicomponent reactions (MCRs)whereby more than two reactants combine in a sequential fashion to give products that retain the majority of the atoms of the starting materials have received much attention during the past 150years 1,2as these can lead to valuable heterocyclic scaffolds in a rapid and highly selective manner.

Well-established examples of such three-component reactions include alkyne trimerization,the Biginelli,Bucherer e Bergs and Gewald reactions,the Hantzsch pyridine synthesis,the Kabach-nik e Fields,Mannich,Passerini,and Pauson e Khand reactions and the Strecker amino acid synthesis.3e 7

Isocyanide-based MCRs are frequently exploited because iso-cyanide is an extraordinary functional group as it displays the re-activity of two extreme resonance forms having either tetravalent or divalent carbon forms.This enables the isocyanide group to undergo both electrophilic and nucleophilic reactions at the divalent carbon atom,which then converts into the tetravalent form in an exo-thermic reaction.The occurrence of isocyanides in natural products has also made it a useful functional group.The two most important isocyanide-based multicomponent reactions are the Passerini three-component reaction to produce a -acyloxy carboxamides and the Ugi four-component reaction,which yields a -acylamino carboxamides.8

Some recent examples of multicomponent reactions using

isocyanide as a component have been reported.9e 132.Results and discussion

Reaction of b -nitrostyrene 1,2-morpholinoethyl isocyanide 2and benzylidenemalononitriles 3a e i in dry tetrahydrofuran (THF)for 36e 48h in the absence of catalyst afforded polysubstituted cyclopentene derivatives 4a e i as single products,which were iso-lated by column chromatography on silica gel (Scheme 1,Table 1).

The structures were identi ?ed based on IR,NMR and HRMS data,X-ray crystallography and physical characteristics.In the IR spectra,

X CN

2

3

rt,36-48h

4

X

NC

NH

NO 2

N

O

H

H THF H

R

R

Scheme 1.Three-component synthesis of cyclopentenes 4a e i .

*Corresponding author.Tel.:t44(0)2920874210;fax:t44(0)2920874030;e-mail addresses:knightdw@https://www.sodocs.net/doc/0c4792196.html, ,knightdw@https://www.sodocs.net/doc/0c4792196.html, (D.W.Knight).Contents lists available at SciVerse ScienceDirect

Tetrahedron

journal h omepage:ww w.el https://www.sodocs.net/doc/0c4792196.html,/locate/tet

0040-4020/$e see front matter ó2012Elsevier Ltd.All rights reserved.https://www.sodocs.net/doc/0c4792196.html,/10.1016/j.tet.2012.10.065

Tetrahedron 69(2013)69e 72

cyano absorptions originating from the benzylidene malononitriles appear at around 2191e 2259cm à1and strong NO 2absorptions arose at around 1628e 1634cm à1,respectively.In the proton NMR spectra,the proton on the NH group,which originated from the 2-morpholinoethyl isocyanide resonated in the region of 9.57e 9.71ppm,as a singlet for 4a ,4d ,4e ,4f ,4g and 4s and as a triplet for 4b ,4c and 4h .Cyclopentene ring protons appeared at around 5.0ppm (the one closer to nitro group)and 4.80ppm as singlets,which can also be considered as supportive of the suggested structure for the cycloadducts.As for 13C NMR spectra,the most deshielded absorptions were observed for cyclopentene ring carbons attached to the NH of the morpholinoethyl group at around 155e 157ppm and,in the case of ester (4i ),phenyl ring carbons at-tached to a nitro group as in 4f (156.7ppm)and 4e where a methoxy substitution is present on the phenyl group (161.59ppm).

Below,a proposed mechanism leading to the formation of pol-ysubstituted cyclopentenes 4a e i is depicted (Scheme 2).Therein,initial nucleophilic attack of isocyanide on the benzylidene

malononitrile produces an intermediate 1,4-dipolar structure.After a resonance delocalization of this,a 1,3-dipolar structure emerges and dipolar cycloaddition to b -nitrostyrene occurs to afford an imino cyclopentane ring,which further tautomerizes to give the polysubstituted cyclopentenes.

These structures were con ?rmed by obtaining an X-ray crystal structure of 4a ;an ORTEP view for compound 4a is presented in Fig.1.The CIF ?les have been deposited at Cambridge Crystallo-graphic Data Center with registry number CCDC 888755.

The asymmetric unit consists of two molecules of 4a ,distin-guishable by the conformation of the chain linking the cyclo-pentene and morpholine rings (Cpen e NH e CH 2e CH 2e torsion angles of 103 and 178 ).Intramolecular N e H /O hydrogen bonding occurs involving one oxygen atom of the nitro group but otherwise molecular geometry is normal (Fig.2).

3.Conclusion

In conclusion,we have developed a three-component reaction of b -nitrostyrene,benzylidene malononitriles and 2-morpholinoethyl isocyanide,which affords highly functionalized cyclopentene derivatives in moderate to good yields via a dipolar cycloaddition in a one-pot operation under catalyst-free conditions.

Table 1

MCRs between b -nitrostyrene 1,isocyanide 2and benzylidene malononitrile 3to give cyclopentenes 4

Ph

NO 2

O N N C

CN

X

N

O

2

2

3

1R

4

+

4R X Time (h)Yield of 4(%)a H CN 3660b 2-Br CN 4848c 4-CF 3CN 3675d 4-Cl CN 3665e 4-OCH 3CN 4845f 4-NO 2CN 3670g 4-CN CN 4868h 4-F CN

4865i a

4-H

COOCH 3

24

75

a

Isolated as a single diastereoisomer of undetermined relative stereochemistry.

N

O

2

N

O

N

O

4

Scheme 2.Proposed mechanism for the formation 4a e i .

Fig.1.X-ray ORTEP view of 4a .

A.Sa g

?rli et al./Tetrahedron 69(2013)69e 7270

4.Experimental

4.1.General information

Melting points were determined on a Ko ?er hot-stage apparatus and are uncorrected.Infrared spectra were recorded on Perkin Elmer-FTIR 1600series spectrophotometer.NMR spectra were recorded on a Bruker DPX 400spectrometer operating at 400MHz for 1H and at 100MHz for 13C at 25 C.13C NMR,COSY,NOESY,HETCOR,HMBC,HSQC spectra recorded at 125MHz were recorded using a Bruker DRX 500instrument.Mass spectra (low and high resolution)were recorded on Fisons VG Platform II,Micromass Q-TOF Micro (ESI-interface)and Waters SYNAPT spectrometers.All chemical shifts are reported in parts per million down ?eld from TMS.Coupling constants (J )are reported in hertz.Multiplicity in 1H NMR is reported as singlet (s),broad singlet (br s),doublet (d),doublet of doublets (dd),triplet (t),and multiplet (m).

Benzylidene malononitriles (3a e h ),methyl 2-cyano-3-phenylacrylate (3i )and b -nitrostyrene were synthesized using lit-erature procedures.14e 16

4.2.Typical procedure for the synthesis of polysubstituted cyclopentene derivatives via three-component reactions A mixture of 2-morpholinoethyl isocyanide 2(70mg,0.5mmol),b -nitrostyrene 1(74.5mg,0.5mmol)and benzylidene malononi-triles (3a e j )(0.5mmol)or methyl 2-cyano-3-phenylacrylate 3i (0.5mmol)was stirred in dry THF (15mL)for the appropriate re-action time (24e 48h)at ambient temperature.After completion of the reaction,which was monitored by TLC,the solvent was evap-orated and the residue was dissolved in diethyl ether (15mL).After 10min,the products precipitated directly from the solution and were ?ltered off and washed with diethyl ether (2?15mL).A ?nal puri ?cation by chromatography using silica gel (ethyl acetate/hexane;2:1)then yielded the pure products 4a e i .

4.2.1.(2RS,5RS)-3-(2-Morpholinoethylamino)-4-nitro-2,5-diphenylcyc-lopent-3-ene-1,1-dicarbonitrile 4a .Light brown powder (60%);mp 171e 173 C;R f :0.26(EtOAc/hexane,2:1);IR (KBr):n max ?3443,2949,2867,2259,1631,1457,1381,1220,698cm à1;1H NMR (400MHz,CDCl 3)d 9.71(s,1H,-N H ),7.62e 7.57(m,3H),7.48e 7.43(m,3H),

7.42e 7.30(m,4H),5.03(s,1H),4.84(s,1H),3.78(s,4H,2?O e CH 2e ),

3.25(br s,1H),3.03(br s,1H),2.60e 2.35(m,6H,3?N e CH 2e );13C NMR (126MHz,DMSO-d 6)d 157.8,135.0,132.4,130.4,130.1,129.4,129.3,129.1,128.3,115.3,11

4.2(C ^N),113.8(C ^N),66.5,56.5,54.3,53.7,53.3,4

5.9,31.1;TOF MS ES t(m /z ,%):444.20(100).HRMS (ESI-TOF,[M tH]t):calcd for C 25H 26N 5O 3,444.2036,found 444.2014.4.2.2.(2RS,5RS)-2-(2-Bromophenyl)-3-(2-morpholinoethylamino)-4-nitro-5-phenylcyclopent-3-ene-1,1-dicarbonitrile 4b .Light brown solid (48%);mp 158e 160 C;R f :0.39(EtOAc/hexane,2:1);IR (KBr):n max ?3237,2956,2849,2249,1634,1440,1388,1234,734cm à1;1H NMR (400MHz,CDCl 3)d 9.57(br s,1H,e N H ),7.84(dd,J ?8.0,1.4Hz,1H),7.50e 7.30(m,7H),7.20(dd,J ?7.7,1.7Hz,1H),5.44(s,1H),5.00(s,1H),3.79(t,J ?4.4Hz,4H),3.26(br s,1H),2.95e 2.88(m,1H),2.62e 2.38(m,6H);13C NMR (100MHz,CDCl 3)d 15

6.0,134.9,133.4,132.6,131.0,130.0,129.6,129.5,128.3,128.0,126.4,116.1,113.8(C ^N),112.4(C ^N),6

7.2,56.5,55.6,55.3,53.6,44.7,31.3;TOF MS ES t(m /z ,%):522.70(100),524.70(M t2,98).HRMS (ESI-TOF,[M tH]t):calcd for C 25H 2579BrN 5O 3,522.1141;found 522.1140.4.2.3.(2RS,5RS)-3-(2-Morpholinoethylamino)-4-nitro-5-phenyl-2-(4-(tri ?uoromethyl)phenyl)cyclopent-3-ene-1,1-dicarbonitrile 4c .Grey solid (75%);mp 150e 152 C;R f :0.36(EtOAc/hexane,2:1);IR (KBr):n max ?3428,2963,2867,2255,1629,1435,1382,1222,700cm à1;1H NMR (400MHz,CDCl 3)d 9.60(br s,1H,e N H ),7.70(d,J ?

8.2Hz,2H),7.45e 7.27(m,7H),4.91(s,1H),4.80(s,1H),3.68(t,J ?4.4Hz,4H),3.18e 3.09(m,1H),2.90e 2.80(m,1H),2.45e 2.35(m,6H);13C NMR (101MHz,CDCl 3)d 155.1,135.1,133.4,ca.133.2(partly obscured d,C e CF 3),130.2,12

9.7,129.5,128.4,128.0,127.6,123.7(q,J ?272Hz,CF 3),116.6,113.5(C ^N),112.9(C ^N),67.3,56.7,56.1,54.9,53.6,46.1,42.0;TOF MS ES t(m /z ,%):512.80(100).HRMS (ESI-TOF,[M tH]t):calcd for C 26H 25F 3N 5O 3,512.1909;found 512.1910.

4.2.4.(2RS,5RS)-2-(4-Chlorophenyl)-3-(2-morpholinoethylamino)-4-nitro-5-phenylcyclopent-3-ene-1,1-dicarbonitrile 4d .Yellow solid (65%);mp 178e 180 C;R f :0.26(EtOAc/hexane,2:1);IR (KBr):n max ?3446,2973,2864,2191,1629,1435,1381,1222,702cm à1;1H NMR (400MHz,CDCl 3)d 9.70(s,1H,e N H ),7.54(d,J ?8.1Hz,2H),7.50e 7.26(m,7H),

5.01(s,1H),4.82(s,1H),3.79(s,4H),3.29e 3.22(m,1H),3.06e 3.03(app.br s,1H),2.55e 2.45(m,6H);13C NMR (100MHz,CDCl 3)d 154.0,13

6.0,132.0,129.5,128.6,128.2,128.1,126.5,115.0,112.1(C ^N),111.6(C ^N),65.7,55.3,54.5,53.4,52.1,44.8,40.4;TOF MS ES t(m /z ,%):478.1631.HRMS (ESI à-TOF,[M àH]t):calcd for C 25H 2335ClN 5O 3,476.1489;found 476.1504.4.2.5.(2RS,5RS)-2-(4-Methoxyphenyl)-3-(2-morpholinoethylamino)-4-nitro-5-phenylcyclopent-3-ene-1,1-dicarbonitrile 4e .Yellow solid (45%);mp 173e 175 C;R f :0.29(EtOAc/hexane,2:1);IR (KBr):n max ?3272,2916,2848,2249,1631,1439,1385,1256,731cm à1;1H NMR (500MHz,CDCl 3)d 9.70(br s,1H,e N H ),

7.48e 7.35(m,3H),7.30e 7.20(m,4H),7.00(d,J ?

8.8Hz,2H),5.00(s,1H),4.78(s,1H),3.85(s,3H,e OC H 3),3.82e 3.73(m,4H),3.28e 3.23(app.br s,1H),3.07e 3.05(app.br s,1H),2.54e 2.43(m,6H);13C NMR (100MHz,CDCl 3)d 161.5(C e OCH 3),156.5,133.7,12

9.9,129.5,129.3,128.4,128.0,122.6,115.9,114.0(C ^N),113.2(C ^N),67.2,56.8,56.2,55.8,54.7,53.6,46.6,41.6;TOF MS ES t(m /z ,%):474.80(100).HRMS (ESI-TOF,[M tNa]t):calcd for C 26H 27N 5NaO 4,496.1961;found 496.2010.4.2.6.(2RS,5RS)-3-(2-Morpholinoethylamino)-4-nitro-2-(4-nitrophe-nyl)-5-phenylcyclopent-3-ene-1,1-dicarbonitrile 4f .Brown solid (70%);mp 158e 160 C;R f :0.29(EtOAc/hexane,2:1);IR (KBr):n max ?3248,2916,2848,2250,1631,1438,1386,1234,729cm à1;1H NMR (400MHz,CDCl 3)d 9.60(br s,1H,e N H ),7.80(d,J ?8.2Hz,2H),7.50e 7.15(m,7H),4.90(s,1H),4.82(br s,1H),3.77e 3.68(m,4H),3.12e 3.08(m,1H),2.90e 2.87(m,1H),2.40(br s,6H);13C NMR (100MHz,CDCl 3)d 154.2,149.5,138.0,133.2,130.3,130.1,129.8,

127.9,

Fig.2.The asymmetric unit consisting of two molecules.

A.Sa g

?rli et al./Tetrahedron 69(2013)69e 7271

125.7,116.8,113.2(C^N),112.8(C^N),67.2,56.7,56.0,54.9,53.6,45.9, 42.1;TOF MS ESt(m/z,%):489.80(100).HRMS(ESI-TOF,[MtH]t): calcd for C25H25N6O5,489.1886;found489.1891.

4.2.7.(2RS,5RS)-2-(4-Cyanophenyl)-3-(2-morpholinoethylamino)-4-nitro-5-phenylcyclopent-3-ene-1,1-dicarbonitrile4g.Yellow solid (68%);mp167e169 C;R f:0.19(EtOAc/hexane,2:1);IR(KBr): n max?3420,2916,2852,2230,1630,1436,1381,1247,729cmà1;1H NMR(400MHz,CDCl3)d9.61(br s,1H,e N H),8.30(d,J?8.6Hz,2H), 7.50(d,J?8.6Hz,2H),7.38e7.33(m,3H),7.25e7.19(m,2H),4.95(s, 1H),4.87(s,1H),3.71(t,J?4.2Hz,4H),3.10(app.br s,1H),2.88(app. br s,1H),2.44e2.36(m,6H);13C NMR(100MHz,DMSO-d6)d156.6, 149.4,137.5,134.7,133.8,130.5,129.2,129.0,128.2,118.5,11

5.2,113.7, 113.4(C^N),113.1(C^N),6

6.5,56.4,53.6,53.2,45.4,42.4;TOF MS ESt(m/z,%):489.80(100).HRMS(ESI-TOF,[MtNa]t):calcd for C26H24N6NaO3,491.1910;found491.1903.

4.2.8.(2RS,5RS)-2-(4-Fluorophenyl)-3-(2-morpholinoethylamino)-4-nitro-5-phenylcyclopent-3-ene-1,1-dicarbonitrile4h.Pale yellow solid(65%);mp167e169 C;R f:0.32(EtOAc/hexane,2:1);IR(KBr): n max?3426,2916,2848,2250,1633,1435,1381,1231,731cmà1;1H NMR(400MHz,CDCl3)d9.60(br s,1H,e N H),7.48e7.10(m,9H), 4.90(s,1H),4.70(s,1H),3.69(app.t,J?4.6Hz,4H),3.20e3.10(m, 1H),2.95e2.87(m,1H),2.50e2.30(m,6H);13C NMR(100MHz, CDCl3)d163.6(d,J?290Hz,C e F),15

5.6,133.5,130.7,130.0,129.6, 127.9,127.0,12

6.9,118.0,11

7.8,113.7(C^N),113.1(C^N),67.2,56.7, 56.0,54.8,53.6,46.3,41.8;TOF MS ESt(m/z,%):462.80(100).HRMS (ESI-TOF,[MtH]t):calcd for C25H25FN5O3,462.1941;found 462.1936.

4.2.9.(1**,2RS,5RS)-Methyl1-cyano-3-(2-morpholinoethylamino)-4-nitro-2,5-diphenylcyclopent-3-ene-carboxylate4i.Light yellow solid (75%);mp195e197 C;R f:0.27(EtOAc/hexane,2:1);IR(KBr): n max?3270,2952,2857,2250,1628,1560,1437,1382,1228, 700cmà1;1H NMR(500MHz,CDCl3)d9.70(br s,1H,N H), 7.40e7.05(m,10H),

5.07(s,1H),5.00(s,1H),3.69(app.t,J?4.4Hz, 4H),3.20(s,3H,e OC H3),3.15e3.07(m,1H),2.92e2.88(m,1H), 2.45e2.25(m,6H);13C NMR(100MHz,CDCl3)d165.8(C]O),161.1 (]C e NH),135.5,134.7,129.8,129.4,128.7,128.6,117.3,115.7(C^N), 6

6.5,56.9,55.5,53.8,53.3,52.4,42.0(three signals obscured);TOF MS ESt(m/z,%):47

7.80(100,[MtH]t).HRMS(ESI-TOF,[MtNa]t): calcd for C26H28NaN4O5,499.1957;found499.1975.

[These data showed product4i to be a single diastereoisomer,of undetermined stereochemistry at C-1.]

4.3.Crystal structure determination

Crystallization of product4a was by slow evaporation of a dichloromethane/ethane solution to yield yellow plates,mp 171e173 C.The best crystal found was twinned and diffracted weakly.Data were recorded on a Nonius Kappa CCD diffractometer equipped with an Oxford Cryosystem cryostat.The structure was solved by direct methods with additional light atoms found by Fourier methods using SHELX97(SHELX97d Programs for Crystal Structure Analysis(Release97-2).G.M.Sheldrick,Instit€u t f€u r Anorganische Chemie der Universit€a t,Tammanstrasse4,D-3400 G€o ttingen,Germany,1998.).Hydrogen atoms were added at cal-culated positions and re?ned using a riding model.Anisotropic displacement parameters were used for all non-H atoms;H-atoms were given isotropic displacement parameters equal to1.2?the equivalent isotropic displacement parameter of the atom to which the H-atom is attached.

The CIF?les have been deposited with the Cambridge Crystal-lographic Data Center with registry number CCDC888755.

C26H24N6O3,M r?468.51,triclinic,P-1,a?12.409(2) A, b?14.641(3) A,c?14.664(2) A,a?72.091(9) ,b?89.802(8) , g?70.013(6) ,V?2367.0(7) A3,Z?4,D x?1.315Mg mà3,l(Mo K a)?

0.71073 A,m?0.089cmà1,F(000)?984,T?150(2)K,crystal size?0.35?0.30?0.10mm3,re?ections collected?8014,independent re?ections?4830,3046with F o>4s(F o),R int?0.0676,?nal R1?0.1340, wR2?0.3347for I>2s(I),and R1?0.19,wR2?0.3745for all data.

Acknowledgements

We are very grateful to a referee for helpful comments. References and notes

1.(a)D€o mling,A.Chem.Rev.2006,106,17e89;(b)Zhu,https://www.sodocs.net/doc/0c4792196.html,.Chem.2003,

7,1133e1144.

2.(a)Orru,R.V.A.;De Greef,M.Synthesis2003,1471e1499;(b)Ban?,L.;Riva,R.

Org.React.2005,65,1e140.

3.Kumar,A.;Maurya,R.A.Tetrahedron2007,63,1946e1952.

4.Kumar,A.;Maurya,R.A.Synlett2008,883e88

5.

5.Kumar,A.;Maurya,R.A.Tetrahedron Lett.2007,48,3887e3890.

6.Kumar,A.;Maurya,R.A.Tetrahedron2008,64,3477e3482.

7.Kumar,A.;Maurya,R.A.Tetrahedron Lett.2007,48,4569e4571.

8.Armstrong,R.W.;Combs,A.P.;Tempest,P.A.;Brown,S.D.;Keating,T.A.Acc.

Chem.Res.1996,29,123e131.

9.Pellegatti,L.;Vedrenne,E.;Hiebel,M.-A.;Buron,F.;Massip,S.;Leger,J.-M.;

Jarry,C.;Routier,S.Tetrahedron Lett.2011,52,5224e5228.

10.Islas-J a come,A.;Gonz a lez-Zamora,E.;G a mez-Monta~n o,R.Tetrahedron Lett.

2011,52,5245e5248.

11.Vlaar,T.;Ruijter,E.;Znabet,A.;Janssen,E.;de Kanter,F.J.J.;Maes,B.U.W.;Orru,

https://www.sodocs.net/doc/0c4792196.html,.Lett.2011,13,6496e6499.

12.Burchak,O.N.;Mugherli,L.;Ostuni,M.;Lacapere,J.J.;Balakirev,M.Y.J.Am.

Chem.Soc.2011,133,10058e10061.

13.Ivachtchenko,A.V.;Ivanenkov,Y.A.;Kysil,V.M.;Krasavin,M.Y.;Ilyin,A.P.

Russ.Chem.Rev.2010,79,787e817.

14.Zhang,M.;Zhang,A.-Q.;Chen,H.-H.;Chen,J.;Chen,https://www.sodocs.net/doc/0c4792196.html,mun.2006,

36,3441e3445.

15.Calheiros,R.;Milhazes,N.;Borges,F.;Marques,M.P.M.J.Mol.Struct.2004,692,

91e106.

16.Guan,X.-Y.;Shi,https://www.sodocs.net/doc/0c4792196.html,.Biomol.Chem.2008,6,3616e3620.

A.Sa g?rli et al./Tetrahedron69(2013)69e72 72

高一英语1月月考试题

高一英语1月月考试题08 （总分：150分；时间：120分钟） 第Ⅰ卷选择题（共105分） 第一部分：听力理解（共两节，满分30分） 第一节（共5小题；每小题1.5分，满分7.5分） 听下面5段对话。每段对话后有一个小题，从题中所给的A、B、C三个选项中选出最佳选项，并标在试卷的相应位置。听完每段对话后，你都有10秒钟的时间来回答有关小题和阅读下一小题。每段对话仅读一遍。 1. Where does the conversation take place probably? A. In a market B. In a shop C. In a garden 2. What are the two speakers going to do? A. Go on a trip by ship B. Walk along the seaside C. Drive out to the shop 3. When does the next train leave for Beijing? A. At 10:30 B. At 10:40 C. At 10:50 4. What can we know from the conversation? A. The woman will make the copies for the man. B. The machine doesn’t work. C. Mike is too busy to help. 5. What do we know about the two speakers? A. They’ve missed the train. B. They’ve got on the wrong train. C. They can’t find Tony on the train. 第二节（共15小题；每题1.5分,满分22.5分） 听下面5段对话或独白。每段对话或独白后有几个小题，从题中所给的A、B、C三个选项中选出最佳选项，并标在试卷的相应位置。听每段对话或独白前，你将有时间阅读各个小题，每小题5秒钟；听完后，各小题将给出5秒钟的作答时间。每段对话或独白读两遍。 听第6 段材料，回答第6、7题。 6. What is the weather like now? A. Fine B. Cloudy C. Windy 7. What is the woman? A. A teacher B. A doctor C. A farmer 听第7 段材料，回答第8至10题。 8. What do we know about the man? A. He has lost his way. B. He has lost something. C. He is going to the park. 9. Why is the man here? A. To be on a business trip. B. To look for a job C. To have a holiday 10. Where does the man work? A. In New York B. In Washington C. In London 听第8段材料，回答第11至13题。 11. What is the relationship between the two speakers?

高一英语竞赛试题(1)

高一英语竞赛试题(1)

2017—2018学年度第一学期英语学科竞赛 高一英语试题 注意事项： 本试卷满分100分，时间为60分钟。本试卷所有答案都涂到答题卡上，试卷上的答案无效，考试完只上交答题卡。 第一部分听力（共两节，满分20分） 第一节（共5小题；每小题1分，满分5分）听下面5段对话。每段对话后有一个小题，从题中所给的A、B、C三个选项中选出最佳选项，并标在试卷的相应位置。听完每段对话后，你都有10秒钟的时间来回答有关小题和阅读下 一小题。每段对话仅读一遍。 1.Why does the woman want the blue sweater? A.It is cheaper. B. She likes blue best. C. It is more fashionable. 2.What is the man probably doing? A.Studying for an exam. B. Writing an 高一英语试题第 2 页 (共30 页)

article. C. Reading a magazine. 3.Who are the speakers talking about? A.The man’s cousin. B. Their friend. C. A singer. 4.Where are the speakers? A.In a hospital. B. In a library. C. In a classroom. 5.How does the woman feel about her job? A.Worried. B. Confident. C. Satisfied. 第二节（共15小题；每小题1分，满分15分） 听下面5段对话或独白。每段对话或独白后 有几个小题，从题中所给的A、B、C三个选项 中选出最佳选项，并标在试卷的相应位置。听每 段对话或独白前，你将有时间阅读各个小题，每 小题5秒钟；听完后，各小题将给出5秒钟的 作答时间。每段对话或独白读两遍。 高一英语试题第 3 页 (共30 页)

高一英语1月月考试题2

高一上学期第二次月考 英语试题 注意事项：本试题分为第Ⅰ卷和第Ⅱ卷两部分，满分150分，考试时间为120分钟。其中第Ⅰ卷为选择题共100分；第Ⅱ卷为非选择题共50分。 第Ⅰ卷（共三部分，满70分） 第一部分听力（30分） 第一节听下面5段对话。每段对话后有一个小题，从题中所给的A、B、C三个选项中选出最佳选项，并标在试卷的相应位置。听完每段对话后，你都有10秒钟的时间来回答有关小题和阅读下一小题。每段对话仅读一遍。 1.What do we know about the restaurant? A.It serves big meals. B. There are many customers. C. It is newly opened. 2.Why does Mary feel so tired? A.She had a long journey. B.She has been working overtime. C.She reviewed her lessons day and night. 3.When does the man work? A.On weekdays only. B. On weekends only. C .On weekends sometimes. 4.Where are the speakers？ A.In a bookstore. B. In a classroom. C. In a library. 5.What is wrong with the man? A.He can not find a toilet. B. He has an upset stomach. C. He has a fever. 第二节听下面5段对话或独白。每段对话或独白后有几个小题，从题中所给的A、B、C 三个选项中选出最佳选项，并标在试卷的相应位置。听每段对话或独白前，你将有时间阅读各个小题，每小题5秒钟；听完后，各小题将给出5秒钟的作答时间。每段对话或独白读两遍。 听下面一段对话，回答6和7两个小题。 6.What is Betty related to the woman? A.Her daughter. B. Her classroom. C. Her cousin. 7.What will Betty do? A.Attend Joan’s party. B. Study in America. C. Visit the woman. 听下面一段对话，回答第8至10三个小题。

高一英语竞赛试题(1)

How does the woman feel about her job? A. Worried. B. Confident. 共 15 小题；每小题 1 分，满分 15 分） 5段对话或独白。每段对话或独白后有几个小题，从题中所给的 A 、B C 三个 选项中选出最佳选项，并标在试卷的相应位置。听每段对话或独白前，你将有时间阅读 各 个小题，每小题 5 秒钟；听完后，各小题将给出 5 秒钟的作答时间。每段对话或独白读两 遍。 听第 6 段材料，回答第 6、 7 题。 6. What does the woman ask the man to do? A. B. C. 7. What has the woman already done? A. She has cancelled the milk and the newspaper.2017—2018 学年度第一学期英语学科竞 赛 高一英语试题 注意事项： 本试卷满分 100分， 时间为 60 分钟。本试卷所有答案都涂到答题卡上，试卷上的答案 无效，考试完只上交答题卡。 第一部分 听力 （共两节，满分 20 分） 第一节（共 5 小题；每小题 1 分，满分 5 分） 听下面 5 段对话。每段对话后有一个小题，从题中所给的 A B 、C 三个选项中选出最 佳选项，并标在试卷的相应位置。听完每段对话后，你都有 10 秒钟的时间来回答有关小题 和阅读下一小题。每段对话仅读一遍。 1. Why does the woman want the blue sweater? A. It is cheaper. B. She likes blue best. C. It is more fashionable. 2. What is the man probably doing? A. Studying for an exam. B. Writing an article. C. Reading a magazine. 3. Who are the speakers talking about? A. The man ' s cousin. B. Their friend. C. A singer. 4. Where are the speakers? A. In a hospital. B. In a library. C. In a classroom. 5. C. Satisfied. 第二节 听下面 Clean her house. Help her move house. Take care of her house.

最新2013年全国中学生英语能力竞赛高一组决赛试题及答案

2013年全国中学生英语能力竞赛高一组试题含答案 （总分：150分答题时间：120分钟） 听力部分（共三大题，记30分） I. Responses (句子应答)（共5小题；每小题1分，记5分） Please listen to the following five sentences and choose the best response to each one you hear. Each sentence will be read only once.(请听句子，然后选出一个能够恰当应答你所听到的句子的最佳选项。每个句子只读 一遍。)（答案涂在答题纸上） 1．A. It’S sunny．B．What a pity．C．I think SO．D．You’d better not． 2．A．I think it’s a western．B．I don’t want to watch that． C．The news is at six fifteen．D．I'll meet you at the school gate． 3．A．I’11 have dinner with you．B．Give me a call at any time． C．It depends on how busy we are．D．Let’S go to see a film． 4．A．Never mind．B．You’re welcome．C．I've no idea．D．That’S wonderful． 5．A．Will 2 o'clock this afternoon be OK? B．That’S really amazing． C．I’ll try my best．D．I like Chinese food best． II. Dialogues(对话理解)（共15小题；每小题1分，记15分） A) Please listen to the following five mini-dialogues. Each dialogue is followed by a question. Choose the best answer or picture for each question. Each dialogue and question will be read twice.(请听下面五组对话，每组对 话后有一个问题，根据你所听到的对话内容，选择能回答所提问的最佳选项。每组对话和问题均读两遍。) (答案涂在答题纸上) 6．A．He went mountain climbing last year．B．He doesn’t want to climb the mountain．C．He hasn't traveled around the world yet．D．He likes mountain climbing very much． 8. A. Italian paintings. B. Modern paintings. C. Traditional paintings. D. Any painting. 9. A. Their neighbour. B. Their daughter. C. Their student. D. Their friend. 10. B) Listen to the following dialogue and choose the best answer to each question. The dialogue will be read twice.(请听下面一段对话，选择能回答下列问题的最佳选项。对话读两遍。) (答案涂在答题纸上) 11. What is the man famous for? A. Doing business. B. Collecting coins. C. Teaching maths. D. Reporting news. 12. When did the man start collecting coins? A. After he had 12 coins. B. When he was 12 years old. C. 12 years before he went to college. D. After he became a professor.

高中英语竞赛试题(含答案)

高中英语竞赛试题(含答案) 第一卷（三部分，共115分） 第一部分：听力（共两节，满分20分） 第一节（共5小题；每小题1分，满分5分） 听下面5段对话。每段对话后有一个小题，从题中所给的A、B、C三个选项中选出最佳选项，并标在试卷的相应位置。听完每段对话后，你有10秒钟的时间来回答有关小题和阅读下一小题。每段对话只读一遍。 1.What caused the fire? A. A careless smoker. B. A broken wire line. C. Some unknown cause. 2.What does the woman mean? A. The man should be the one to speak to Paul. B. The man should repair the radio himself. C. There is no need for him to say “sorry”. 3.Where are the two speakers having the dialogue? A. In the street. B. On a bus C. At the bus stop. 4.What does the woman mean? A. The old house should be turned into stores. B. The shop center is quite old. C. New shopping center are very common. 5.Where does the woman prefer to live? A. In the countryside. B. In the city. C. In the small town. 第二节（共15小题；每小题1分，满分1 5分） 听下面5段对话或独白。每段对话或独白后有几个小题，从题中所给的A、B、C三个选项中选出最佳选项，并标在试卷的相应位置。听每段对话或独白前，你将会有时间阅读各个小题，每小题5秒钟；听完后，你有5秒钟的作答时间。每段对话只读两遍。 听第6段材料，回答第6、7两个小题。 6.Where does the conversation take place? A. At the ticket office. B. On the plane. C. At the check in counter. 7.What will the woman have to carry to reduce the weight of her luggage? A. The shoulder bag. B. The dictionary. C. The hand bag. 听第7段材料，回答第8至10三个小题。 8.What tickets does the man want to buy? A. For the pop star sport. B. For pop music concerts. C. For the music conference. 9.On which day will the man g to the concert? A. Thursday. B. Friday. C. Sunday 10.Which of the following does the man least care about? A. The date of the ticket. B. The price of the ticket. C. Whether the seats are together or not. 听第8段材料，回答第11至13三个小题。 11.Where does the conversation take place? A. In a cafeteria（自助食堂） B. In a café. C. In a bar.

广东省深圳市普通高中2017-2018学年高一英语1月月考试题02

高一英语1月月考试题02 一. 听力（满分10分） 第一节（共5小题；每小题1分，满分5分）听下面5段对话。每段对话后有一个小题，从题中所给的A、B、C三个选项中选出最佳选项，并标在试卷的相应位置。听完每段对话后，你都有10秒钟的时间来回答有关小题和阅读下一小题。每段对话仅读一遍。 1. When will the woman most probably meet the man? A. At 6:00. B. At 6:15. C. At 6:30. 2. Where does this conversation most probably take place? A. In a theater. B. In an office. C. In a restaurant. 3. Where does this conversation take place? A. In a clothing shop. B. In a restaurant. C. In an office. 4. What will the man do first? A. Read the operation manual. B. Try the buttons one by one. C. Have the machine repaired. 5. What do we know about the woman? A. She used to work in a car company. B. She wishes to have a different kind of job. C. She’d like her manager’s opinion on her work. 第二节（共5小题，每小题1分，满分5分） 听下面2段对话，每段对话后有两个问题，从题中所给的A、B、C三个选项中选出最佳选项。听完每段对话后，你有5秒的时间来回答有关小题或阅读下面的小题。每段读两遍。 听第6段材料，回答第6至7题 6. What is the most probable relationship between the two speakers? A. Guard and worker. B. Driver and passenger. C. Employer and employee. 7. Why is the man often late for work? A. He cares for his aunt. B. He gets caught in traffic. C. He doesn’t like his work hours. 听第7段材料，回答第8至10题 8. Who is answering the phone? A. Judy’s brother. B. Susan’s cousin. C. Judy’s cousin. 9. What has happened to Susan’s bat? A. It’s stolen. B. It’s lost. C. It’s broken. 10. What does Susan ask Judy to do tomorrow? A. Bring the book and the extra bat. B. Call Susan and her cousin back. C. Play table tennis with her brother. 二. 单项选择:（10%）（共20小题，每小题0.5分，共计10分） 从A，B，C，D四个选项中，选出可以填入空白处的最佳选项，并在答题纸上将该项涂黑。11. ----I’d like a cup of coffee, please. Play table tennis with her brother. ----How do you like it ? . ---- .

高一英语竞赛试题(1)(完整资料)

此文档下载后即可编辑 2017—2018学年度第一学期英语学科竞赛 高一英语试题 注意事项： 本试卷满分100分，时间为60分钟。本试卷所有答案都涂到答题卡上，试卷上的答案无效，考试完只上交答题卡。 第一部分听力（共两节，满分20分） 第一节（共5小题；每小题1分，满分5分） 听下面5段对话。每段对话后有一个小题，从题中所给的A、B、C三个选项中选出最 佳选项，并标在试卷的相应位置。听完每段对话后，你都有10秒钟的时间来回答有关小题 和阅读下一小题。每段对话仅读一遍。 1.Why does the woman want the blue sweater? A.It is cheaper. B. She likes blue best. C. It is more fashionable. 2.What is the man probably doing? A.Studying for an exam. B. Writing an article. C. Reading a magazine. 3.Who are the speakers talking about? A.The man’s cousin. B. Their friend. C. A singer. 4.Where are the speakers? A.In a hospital. B. In a library. C. In a classroom. 5.How does the woman feel about her job? A.Worried. B. Confident. C. Satisfied. 第二节（共15小题；每小题1分，满分15分） 听下面5段对话或独白。每段对话或独白后有几个小题，从题中所给的A、B、C三个 选项中选出最佳选项，并标在试卷的相应位置。听每段对话或独白前，你将有时间阅读各 个小题，每小题5秒钟；听完后，各小题将给出5秒钟的作答时间。每段对话或独白读两遍。 听第6段材料，回答第6、7题。 6.What does the woman ask the man to do? A.Clean her house. B.Help her move house. C.Take care of her house. 7.What has the woman already done? A.She has cancelled the milk and the newspaper.

2018-2019学年高一上学期第一次月考英语试题 含答案

2018~2019学年高一上学期第一次月考 英语 （考试时间：100分钟试卷满分：120分） 第一部分阅读理解（共两节，满分40分）第一节（共15小题；每小题2分，满分30分） 阅读下面短文，从每题所给的A、B、C和D四个选项中选出最佳选项。 A Summer vacation is coming. Most of students want to have a good trip this summer. Here is some information about trips for you. 1．Which number should you dial if you want to take hot spring? A．4325116. B．4258663. C．4325611. D．4325711. 2．If you want to go to the Pine Sea, you can't enter_______. A．at 10 :00 am B．at 6 :00 pm C．at 11 :00am D．at 2 :00 pm 3．If a couple with a 5-year-old child go to the Big Valley, how much should they pay? A．￥160.00. B．￥280.00. C．￥440.00. D．￥320.00. 4．Where can you go for hiking? A．The Stone Sea. B．The Pine Sea. C．The Big Valley. D．The Grass Lake. B

2019高一英语竞赛模拟试题

高一英语竞赛模拟试题 以下是为大家整理的关于《高一英语竞赛模拟试题》的文章，供大家学习参考！ A)从A、B、C、D四个选项中,选出可以填入空白处的选项。 1.Don't read__________ books__________ you can not understand. A.same;as B.such;what C.the same;with D.such;as 2.—Do you know Taylor Smith? —I remember the name but 胡已I can't remember__________ . A.what does he look like B.what he looks like C.he looks like what D.like what he looks 3.—Will you come? —If Mary doesn't come,__________ . A.so will I B.so do I C.neither will I D.either do I 4.The teacher had explained the sentence to me,but I__________ didn't understand. A.still B.yet C.always D.already 5.Do you find__________ necessary that I should wear glasses? A.what B.it C.that D.不填 6.Put on this raincoat,please.The umbrella can't keep the heavy rain__________ . A.under B.up C.on D.out 7.My father bought me__________ table yesterday. A.a round small wooden B.a small round wooden C.round small a wooden D.a wooden round small 8.The soldier hardly knew__________ use the new gun,__________ ? A.what to;did he B.how to;didn't he C.when to;didn't he D.how to;did he 9.Several of the stories show how man is__________ . A.losing his ability to live a rich and meaningful life B.less and less able to live a rich life with meaning C.losing his ability to live a rich life and that his life is losing meaning D.becoming poor of spirit and that meaning is gone from his life 10.Alice is well known__________ her sweet voice__________ all of us. A.for;to B.about;for C.because of;for D.as;to 11.He was__________ down by a car and was sent to hospital in a hurry. A.pulled B.put C.knocked D.made 12.—Is Tom an army man? —No,he is__________ the army. A.too young to join B.very young to join C.enough old to join D.too young not to join 13.__________ Jack__________ !He didn't have time for rest. A.What;is B.How;worked C.How;is D.What;worked 14.He was a poor teacher who made very little money. Luckily his wife was a good housekeeper who knew how to make a little money go a long way. A.manage her household

少数民族传统节日表汇编

中国少数民族主要节日 民族主要节日时间 阿昌族火把节农历六月二十五日会街节农历九月初十 泼水节农历二月二十九日撒神农历七月初一 尝新节农历八月十五日 白族三月街农历三月十五日火把节农历六月二十四日渔潭会农历八月十五日 保安族圣纪节伊斯兰教历三月十二日开斋节伊斯兰教历九月三十日古尔邦节伊斯兰教历十二月十日 布郎族开门节傣历十二月十五日关门节傣历九月十五日泼火节农历二月十九日 布依族 六月六农历六月初六 三月三农历三月初三朝鲜族 元日农历正月初一 上元节农历正月初五 寒食节农历四月初五 端午农历五月初五 哈尼族 十月节农历十月初一 六月节农历六月二十四日 哈萨克族 圣纪节伊斯兰教历三月十二日 开斋节伊斯兰教历九月三十日 古尔邦节伊斯兰教历十二月十日赫哲族赫哲年农历正月初一 回族 圣纪节伊斯兰教历三月十二日 开斋节伊斯兰教历九月三十日 古尔邦节伊斯兰教历十二月十日基诺族 打铁节农历一月 火把节农历六月 京族哈节农历六月初十 德昂族泼水节农历四月十五日 东乡族 圣纪节伊斯兰教历三月十二日 开斋节伊斯兰教历九月三十日 古尔邦节伊斯兰教历十二月十日

四月八农历四月初八 朝鲜族元日农历正月初一上元节农历正月初五寒食节农历四月初五端午农历五月初五 哈尼族 十月节农历十月初一 六月节农历六月二十四日 哈萨克族圣纪节伊斯兰教历三月十二日开斋节伊斯兰教历九月三十日古尔邦节伊斯兰教历十二月十日 赫哲族赫哲年农历正月初一 回族圣纪节伊斯兰教历三月十二日开斋节伊斯兰教历九月三十日古尔邦节伊斯兰教历十二月十日 基诺族 打铁节农历一月 火把节农历六月 京族哈节农历六月初十 德昂族泼水节农历四月十五日 东乡族圣纪节伊斯兰教历三月十二日

高一英语1月月考试题

浙江省诸暨市2017-2018学年高一英语1月月考试题 第一部分：听力（共20小题；每小题 1.5分，满分30分） 第一节 听下面5段对话,每段对话后有一小题,从题中所给的A,B,C三个选项中选出最佳选项,并标在试卷的相应位置,听完每段对话后,你都有15秒钟的时间来回答有关小题和阅读下一小题。每段对话只读一遍。 1.How will the man go home？ A.By bike. B.By subway. C.By bus. 2.What happened to the woman’s son? A.He hurt his arm. B.He had a headache. C.He got pains in his fingers. 3.What will the man do tonight? A.Do his homework. B.Watch Tv. C.Play football. 4.What is Mary’s phone number? A.97756431. B.86727151. C.86727115. 5.What is the man looking for? A.A computer. B.A cup of tea. C.A book. 第二节 听下面5段对话或独白,每段对话或独白后有几个小题,从题中所给的A、B、C三个选项中选出最佳选项,并标在试卷的相应位置。听每段对话或独白前,你将有时间来阅读各个小题,每小题5秒钟；听完后,各小题将给出5秒钟的作答时间。每段对话或独白读两遍。 听第6段材料,回答第6、7题。 6.What will the woman do for Albert’s birthday? A.Decorate his room. B. Organize a party C.prepare a big dinner. 7.What does the woman ask the man to bring? A.Juice B. A cake. C. Fruit. 听第7段材料,回答第8、9题。 8.What are the speakers mainly talking about? A. An interview. B.An English class C.A piece of homework. 9.What did Mr. Gray talk a lot about? A.The methods of learning English. B.The culture of some countries. C.The rules in the classroom. 听第8段材料,回答第10至12题。 10.What has the man decided to do for his holiday? A.Go climbing B. Go hiking C. Go camping. 11.How long will the man be away？ A. Seven days. B. Six days. C. Five days. 12.What is the woman’s opinion about hiking and climbing?

高一英语竞赛试题

河南省郑州四中09-10学年高一竞赛试题（英语） 命题人：岳桂英校对：蒙曌琦 试卷说明： 1.本试卷分第一卷和第二卷两部分，第一卷从第1页到第3页，第二卷从第4页到第5页， 共5页；满分120分；考试时间100分钟。 2．第一卷答案请用铅笔涂写在答题卡上，第二卷答题要求请看答题卷第1-2卷。 3．交卷时只交答题卡和答题卷。 第一卷 第一部分英语知识运用 (共两节，满分30分) 第一节：单项填空（共15题；每小题1分，满分15分） 1. I really don't know______ I had my money stolen . A . when was it that B . that it was when C . where it was that D . it was where that 2. Father went to his doctor for ______ about his heart trouble . A . an advice B . advice C . advices D . the advices 3. You really don't know what we ______ while we were working on this project . A . went through B . go through C . go across D . go down 4.The doctor ______ a cure for the disease . A .came over to B. came out from C . came on D . came up with 5. Can you tell me the name of the school ______ you visited last week? A. what B. where C. who D. which 6. I couldn’t move my legs. It was ______ they were stuck to the floor. A. as if B. so that C. as long as D. even if 7. Is this factory ______ the foreign investors are going to visit next month? A. the one B. that C. where D. What 8. Whenever we’re in ________, we should never lose ______ but try to think of the way out. A. the trouble; our hearts B. troubles; hearts C. trouble; heart D. the trouble; the heart 9. —How are you getting along with your studies? —Not very well, ______． A．of course B．I’m sure C．I’m afraid D．on the other hand 10. He is the man _________ you can turn when you are in trouble. A. that B. which C. to whom D. to him 11. At last, they came to a beautiful island, _____ they enjoyed a good picnic. A. which B. where C. there D. on it 12. They consider that vase to be a treasure, but in my opinion, it is just a ______ bottle. A. valuable B. rare C. common D. worth 13. — What did you think of the film last night? — Really wonderful! It’s well worth _____. A. seeing B. to see C. being seen D. to be seen 14. Because the two countries were at _____ war, the people had ______ hard

高一英语竞赛精彩试题(1)

2017—2018学年度第一学期英语学科竞赛 高一英语试题 注意事项： 本试卷满分100分，时间为60分钟。本试卷所有答案都涂到答题卡上，试卷上的答案无效，考试完只上交答题卡。 第一部分听力（共两节，满分20分） 第一节（共5小题；每小题1分，满分5分） 听下面5段对话。每段对话后有一个小题，从题中所给的A、B、C三个选项中选出最 佳选项，并标在试卷的相应位置。听完每段对话后，你都有10秒钟的时间来回答有关小题 和阅读下一小题。每段对话仅读一遍。 1.Why does the woman want the blue sweater? A.It is cheaper. B. She likes blue best. C. It is more fashionable. 2.What is the man probably doing? A.Studying for an exam. B. Writing an article. C. Reading a magazine. 3.Who are the speakers talking about? A.The man’s cousin. B. Their friend. C. A singer. 4.Where are the speakers? A.In a hospital. B. In a library. C. In a classroom. 5.How does the woman feel about her job? A.Worried. B. Confident. C. Satisfied. 第二节（共15小题；每小题1分，满分15分） 听下面5段对话或独白。每段对话或独白后有几个小题，从题中所给的A、B、C三个 选项中选出最佳选项，并标在试卷的相应位置。听每段对话或独白前，你将有时间阅读各 个小题，每小题5秒钟；听完后，各小题将给出5秒钟的作答时间。每段对话或独白读两遍。 听第6段材料，回答第6、7题。 6.What does the woman ask the man to do? A.Clean her house. B.Help her move house. C.Take care of her house. 7.What has the woman already done? A.She has cancelled the milk and the newspaper.