Helioxanthin derivative 5-4-2_HBVHSV-1HSV-2病毒抑制剂_203935-39-1_Apexbio

产品名: Helioxanthin derivative 5-4-2修订日期: 6/30/2016产品说明书

化学性质

产品名:

Helioxanthin derivative 5-4-2

Cas No.:

203935-39-1 分子量:

347.32 分子式: C20H13NO5

化学名:

10-(benzo[d][1,3]dioxol-5-yl)-9H-[1,3]dioxolo[4',5':3,4]benzo[1,2-f]is oindol-7-ol SMILES:

OC1=NCC2=C1C=C3C=CC(OCO4)=C4C3=C2C5=CC6=C(OCO6)C=C5 溶解性:

Soluble in DMSO 储存条件:

Store at -20°C 一般建议: For obtaining a higher solubility , please warm the tube at 37°C

and shake it in the ultrasonic bath for a while.Stock solution can be

stored below -20°C for several months.

运输条件:

Evaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

生物活性

靶点 :

Microbiology & Virology 信号通路:

HBV 产品描述:

Helioxanthin derivative 5-4-2是helioxanthin (ACH126447)的类似物,是HBV\HSV-1和HSV-2的小分子抑制剂,EC50值分别为0.08 μM\0.29 μM 和0.16 μM [1].

Helioxanthin derivative 5-4-2是一种内酰胺,对HBV 的 DNA\RNA 及病毒蛋白表达具有抑制作用[2].Helioxanthin derivative 5-4-2具有显著的抗病毒活性,对HBV(肝炎B 病毒), HSV-1(1

型单

纯疱疹病毒)和HSV-2(2型单纯疱疹病毒)的EC50值分别为0.08 μM\0.29 μM 和0.16 μM [1] .另外,Helioxanthin derivative 5-4-2通过对必需转录因子的转录后下调,抑制HBV复制[3].Helioxanthin derivative 5-4-2具有有效抗HCV(肝炎病毒C)活性,1.0 μM能够抑制55%,3.0 μM能够抑制80% [1].

参考文献:

[1]. Yeo H1, Li Y, Fu L, Zhu JL, Gullen EA, Dutschman GE, Lee Y, Chung R, Huang ES, Austin DJ, Cheng YC. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan

27;48(2):534-46.

[2]. Li Y1, Fu L, Yeo H, Zhu JL, Chou CK, Kou YH, Yeh SF, Gullen E, Austin D, ChengYC.Inhibition of hepatitis B virus gene expression and replication by helioxanthin and its derivative. Antivir Chem Chemother. 2005;16(3):193-201.

[3]. Stein LL1, Loomba R. Drug targets in hepatitis B virus infection. Infect Disord Drug Targets. 2009 Apr;9(2):105-16.

特别声明

产品仅用于研究，

不针对患者销售，望谅解。

每个产品具体的储存和使用信息显示在产品说明书中。ApexBio产品在推荐的条件下是稳定的。产品会根据不同的推荐温度进行运输。许多产品短期运输是稳定的，运输温度不同于长期储存的温度。我们确保我们的产品是在保持试剂质量的条件下运输的。收到产品后，按照产品说明书上的要求进行储存。

ApexBio Technology