NGAL、KIM—1和IL—18三者联合检测在儿童急性肾损伤早期诊断中的意义
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NGAL、KIM—1和IL—18三者联合检测在儿童急性肾损伤早期诊断中的意义
作者：潘国权等
来源：《中国现代医生》2015年第09期
[摘要] 目的探讨NGAL、KIM-1和IL-18三者联合检测在儿童急性肾损伤（acute kidney injury，AKI）早期诊断中的意义。方法选取2011年6月～2013年6月在我院PICU的100例危重症患儿为研究对象，分为AKI组（40例）与非AKI组（n=60）。收集两组患儿晨起尿液6～8 mL，用酶联免疫吸附法检测尿液中 NGAL、IL-18和 KIM-1 水平，并将三个指标与血清肌酐进行比较，同时绘制ROC曲线，评价尿 NGAL、IL-18 和 KIM-1 在 AKI 早期诊断中价值。结果 AKI组与非AKI组在年龄、性别、收缩压、舒张压、尿比重上无明显差异
（P>0.05）；AKI组与非AKI组比较，Scr、NGAL、KIM-1以及IL-18水平，均显著提高，差异有统计学意义（P
[关键词] 急性肾损伤；儿童；中性粒细胞明胶酶相关脂质运载蛋白；肾损伤分子 1
[中图分类号] R726.9 [文献标识码] B [文章编号] 1673-9701（2015）09-0067-03
NGAL， KIM-1 and IL-18 three injury early diagnostic value in children with acute kidney
FAN Guoquan1 LIANG Yafeng1 LIN Beibei1 TANG Zhenhai1 CHEN Xu1 WANG Linxia1 CHEN Minguang2
1.Department of Pediatric Intensive Care Unit， the Second Affiliated Hospital & Yuying Children’s Hospital， Wenzhou Medical University，Wenzhou 325000，China；
2.Department of Pediatric Nephrology，the Second Affiliated Hospital & Yuying Children’s Hospital， Wenzhou Medical University，Wenzhou 325000，China
[Abstract] Objective To discuss the significance of combined detection of NGAL， KIM-1 and IL-18 three in children with acute kidney injury in the diagnosis of early research. Methods From June 2011 to June 2013 in our hospital，100 cases of critically ill children with PICU as the research object， and were divided into group AKI（40 cases） and non AKI group（60 cases）. The collection of two groups of children with early morning urine 6-8 ml by enzyme linked immunosorbent assay（enzyme-linked immunosorbent， assay， ELISA） NGAL detection in urine， IL-18 and KIM-1 levels， and the three indexes and serum creatinine （serum creatinine，Scr） compared， at the same time to draw the ROC curve， evaluation of urinary NGAL， IL-18 and KIM-1 in the AKI value early diagnosis. Results The patients in the AKI group and non AKI group patients in age and sex， systolic blood pressure， diastolic blood pressure， urine specific gravity without obvious difference， and the difference had no statistical significance （P>0.05）；