Atovaquone_DataSheet_MedChemExpress
Inhibitors, Agonists, Screening Libraries
https://www.sodocs.net/doc/949471985.html, Data Sheet
BIOLOGICAL ACTIVITY:
Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.
Target: Antiparasitic
Atovaquone (atavaquone) is a chemical compound that belongs to the class of naphthalenes. Atovaquone is a
hydroxy–1,4–naphthoquinone, an analog of ubiquinone, with antipneumocystic activity [1]. Atovaquone is an anti–protozoal
mitochondrial electron transport inhibitor; Antimalarial; Antipneumocystic, and has also been used to treat toxoplasmosis. It acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron–sulfur protein and cytochrome b in the ubiquinol oxidation pocket [2]. Atovaquone is a unique naphthoquinone with broad–spectrum antiprotozoal activity. It is effective for the
treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis [3].
References:
[1]. Looareesuwan, S., et al., Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand. Am J Trop Med Hyg, 1996. 54(1): p. 62–6.
[2]. Kessl, J.J., et al., Molecular basis for atovaquone binding to the cytochrome bc1 complex. J Biol Chem, 2003. 278(33): p. 31312–8.
[3]. Baggish, A.L. and D.R. Hill, Antiparasitic agent atovaquone. Antimicrobial agents and chemotherapy, 2002. 46(5): p. 1163–1173.
Product Name:
Atovaquone Cat. No.:
HY-13832CAS No.:
95233-18-4Molecular Formula:
C 22H 19ClO 3Molecular Weight:
366.84Target:
Parasite Pathway:
Anti–infection Solubility:
10 mM in DMSO
Caution: Product has not been fully validated for medical applications. For research use only.
Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@https://www.sodocs.net/doc/949471985.html, Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
https://www.sodocs.net/doc/949471985.html,