6-Aminochrysene_DataSheet_MedChemExpress

Inhibitors, Agonists, Screening Libraries

https://www.sodocs.net/doc/af19022737.html, Data Sheet

BIOLOGICAL ACTIVITY:

6–Aminochrysene (6–Aminochrysene) is an aromatic amine used as a chemotherapeutic agent in the treatment of splenomegaly,myeloid leukemia, and breast cancer.

In Vitro: 6–Aminochrysene inhibits the hydroxylation of aniline, 0–demethylation of p–nitroanisole, and N–demethylation of

aminopyrine by rat liver microsomes. Pre–treatment of rats with 6–aminochrysene markedly decreases the N–demethylation in vitro b ut significantly increases the hydroxylation and the 0–demethylation [1].

In Vivo: 6–Aminochrysene is an inhibitor of the growth of several solid experimental tumours in vivo and has a cancerostatic effect on human breast cancer [1]. Long term topical skin application of 6–Aminochrysene to mice induces development of benign skin tumors after 3 months and of skin malignancies after 7 months. Female mice respond earlier than males. Induction of skin tumors is more rapid when 6–Aminochrysene is applied ventrally instead of dorsally. Urinary excretion is about twice as high after skin application than after oral administration [2].

PROTOCOL (Extracted from published papers and Only for reference)

Animal Administration: 6–Aminochrysene is emulsified in physiological saline with Tween 80 (10 mg/mL in 5% Tween solution) [1].[1]Ra t: Male CD rats are pre–treated with 25, 50 and 100 mg/kg of 6–Aminochrysene intraperitoneally once daily for 3 consecutive days before sacrifice, which is performed 24 h after the last administration. Controls receive only the solvent [1].

References:

[1]. Russo R, et al. Effects of 6–aminochrysene on liver microsomal enzyme activity. Xenobiotica. 1976 Apr;6(4):201–5.

[2]. Lambelin G, et al. Carcinogenicity of 6–aminochrysene in mice. Eur J Cancer. 1975 May;11(5):327–34.

Product Name:

6–Aminochrysene Cat. No.:

HY-108315CAS No.:

2642-98-0Molecular Formula:

C18H13N Molecular Weight:

243.30Target:

Others Pathway:

Others Solubility:

DMSO: ≥62.5 mg/mL

Caution: Product has not been fully validated for medical applications. For research use only.

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