cancer census 癌症基因谱

ABL2v-abl Abelson murine leukemia viral oncogene homolog 227 ACSL3acyl-CoA synthetase long-chain family member 32181

AF15Q14AF15q14 protein57082

AF1Q ALL1-fused gene from chromosome 1q10962

AF3p21SH3 protein interacting with Nck, 90 kDa (ALL1 fused gene from 3p21)51517

AF5q31ALL1 fused gene from 5q3127125 AKAP9 A kinase (PRKA) anchor protein (yotiao) 910142 AKT1v-akt murine thymoma viral oncogene homolog 1207 AKT2v-akt murine thymoma viral oncogene homolog 2208 ALDH2aldehyde dehydrogenase 2 family (mitochondrial)217

ALK anaplastic lymphoma kinase (Ki-1)238 ALO17KIAA1618 protein57714 APC adenomatous polyposis of the colon gene324 ARHGEF12RHO guanine nucleotide exchange factor (GEF) 12 (LARG)23365 ARHH RAS homolog gene family, member H (TTF)399 ARID1A AT rich interactive domain 1A (SWI-like)8289 ARID2AT rich interactive domain 2196528 ARNT aryl hydrocarbon receptor nuclear translocator405 ASPSCR1alveolar soft part sarcoma chromosome region, candidate 179058 ASXL1additional sex combs like 1171023 ATF1activating transcription factor 1466 ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP471 ATM ataxia telangiectasia mutated472 ATRX alpha thalassemia/mental retardation syndrome X-linked546 BAP1BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)8314 BCL10B-cell CLL/lymphoma 108915 BCL11A B-cell CLL/lymphoma 11A53335 BCL11B B-cell CLL/lymphoma 11B (CTIP2)64919 BCL2B-cell CLL/lymphoma 2596 BCL3B-cell CLL/lymphoma 3602 BCL5B-cell CLL/lymphoma 5603 BCL6B-cell CLL/lymphoma 6604 BCL7A B-cell CLL/lymphoma 7A605 BCL9B-cell CLL/lymphoma 9607 BCOR BCL6 corepressor54880 BCR breakpoint cluster region613 BHD folliculin, Birt-Hogg-Dube syndrome201163 BIRC3baculoviral IAP repeat-containing 3330 BLM Bloom Syndrome641 BMPR1A bone morphogenetic protein receptor, type IA657 BRAF v-raf murine sarcoma viral oncogene homolog B1673 BRCA1familial breast/ovarian cancer gene 1672 BRCA2familial breast/ovarian cancer gene 2675 BRD3bromodomain containing 38019 BRD4bromodomain containing 423476 BRIP1BRCA1 interacting protein C-terminal helicase 183990 BTG1B-cell translocation gene 1, anti-proliferative694

BUB1B BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)701

C12orf9chromosome 12 open reading frame 993669

C15orf21chromosome 15 open reading frame 21283651

C15orf55chromosome 15 open reading frame 55256646

C16orf75chromosome 16 open reading frame 75116028

C2orf44chromosome 2 open reading frame 4480304 CAMTA1calmodulin binding transcription activator 1611501 CANT1calcium activated nucleotidase 1124583 CARD11caspase recruitment domain family, member 1184433 CARS cysteinyl-tRNA synthetase833 CBFA2T1core-binding factor, runt domain, alpha subunit 2;translocated to, 1 (ET862 CBFA2T3core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (MT863 CBFB core-binding factor, beta subunit865 CBL Cas-Br-M (murine) ecotropic retroviral transforming867 CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b868 CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c23624 CCDC6coiled-coil domain containing 68030 CCNB1IP1cyclin B1 interacting protein 1, E3 ubiquitin protein ligase57820 CCND1cyclin D1595 CCND2cyclin D2894 CCND3cyclin D3896 CCNE1cyclin E1898 CD273programmed cell death 1 ligand 280380 CD274CD274 molecule29126 CD74CD74 molecule, major histocompatibility complex, class II invariant cha972

CD79A CD79a molecule, immunoglobulin-associated alpha973

CD79B CD79b molecule, immunoglobulin-associated beta974 CDH1cadherin 1, type 1, E-cadherin (epithelial) (ECAD)999 CDH11cadherin 11, type 2, OB-cadherin (osteoblast)1009 CDK12cyclin-dependent kinase 1251755 CDK4cyclin-dependent kinase 41019 CDK6cyclin-dependent kinase 61021 CDKN2A cyclin-dependent kinase inhibitor 2A (p16(INK4a)) gene1029 CDKN2a(p14)cyclin-dependent kinase inhibitor 2A-- p14ARF protein1029 CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)1031 CDX2caudal type homeo box transcription factor 21045 CEBPA CCAAT/enhancer binding protein (C/EBP), alpha1050 CEP1centrosomal protein 111064 CHCHD7coiled-coil-helix-coiled-coil-helix domain containing 779145 CHEK2CHK2 checkpoint homolog (S. pombe)11200 CHIC2cysteine-rich hydrophobic domain 226511 CHN1chimerin (chimaerin) 11123 CIC capicua homolog23152 CIITA class II, major histocompatibility complex, transactivator4261 CLTC clathrin, heavy polypeptide (Hc)1213 CLTCL1clathrin, heavy polypeptide-like 18218 CMKOR1chemokine orphan receptor 157007 COL1A1collagen, type I, alpha 11277 COPEB core promoter element binding protein (KLF6)1316 COX6C cytochrome c oxidase subunit VIc1345 CREB1cAMP responsive element binding protein 11385

CREB3L1cAMP responsive element binding protein 3-like 190993 CREB3L2cAMP responsive element binding protein 3-like 264764 CREBBP CREB binding protein (CBP)1387 CRLF2cytokine receptor-like factor 264109 CRTC3CREB regulated transcription coactivator 364784 CTNNB1catenin (cadherin-associated protein), beta 11499 CYLD familial cylindromatosis gene1540

D10S170DNA segment on chromosome 10 (unique) 170, H4 gene (PTC1)8030 DAXX death-domain associated protein1616 DDB2damage-specific DNA binding protein 21643 DDIT3DNA-damage-inducible transcript 31649 DDX10DEAD (Asp-Glu-Ala-Asp) box polypeptide 101662 DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 51655 DDX6DEAD (Asp-Glu-Ala-Asp) box polypeptide 61656 DEK DEK oncogene (DNA binding)7913 DICER1dicer 1, ribonuclease type III 23405 DNM2dynamin 21785 DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha1788 DUX4double homeobox, 422947 EBF1early B-cell factor 11879 ECT2L epithelial cell transforming sequence 2 oncogene-like345930 EGFR epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b)1956

EIF4A2eukaryotic translation initiation factor 4A, isoform 21974 ELF4E74-like factor 4 (ets domain transcription factor)2000 ELK4ELK4, ETS-domain protein (SRF accessory protein 1)2005 ELKS ELKS protein23085 ELL ELL gene (11-19 lysine-rich leukemia gene)8178 ELN elastin2006 EML4echinoderm microtubule associated protein like 427436

EP300300 kd E1A-Binding protein gene2033 EPS15epidermal growth factor receptor pathway substrate 15 (AF1p)2060 ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/gliob2064 ERCC2excision repair cross-complementing rodent repair deficiency, complem2068 ERCC3excision repair cross-complementing rodent repair deficiency, complem2071 ERCC4excision repair cross-complementing rodent repair deficiency, complem2072 ERCC5excision repair cross-complementing rodent repair deficiency, complem2073 ERG v-ets erythroblastosis virus E26 oncogene like (avian)2078 ETV1ets variant gene 12115 ETV4ets variant gene 4 (E1A enhancer binding protein, E1AF)2118 ETV5ets variant gene 52119 ETV6ets variant gene 6 (TEL oncogene)2120

EVI1ecotropic viral integration site 12122 EWSR1Ewing sarcoma breakpoint region 1 (EWS) 2130 EXT1multiple exostoses type 1 gene2131 EXT2multiple exostoses type 2 gene2132 EZH2enhancer of zeste homolog 22146 EZR ezrin7430 FACL6fatty-acid-coenzyme A ligase, long-chain 623305 FAM22A family with sequence similarity 22, member A728118 FAM22B family with sequence similarity 22, member B729262 FAM46C family with sequence similarity 46, member C54855

FANCA Fanconi anemia, complementation group A2175 FANCC Fanconi anemia, complementation group C2176 FANCD2Fanconi anemia, complementation group D22177 FANCE Fanconi anemia, complementation group E2178 FANCF Fanconi anemia, complementation group F2188 FANCG Fanconi anemia, complementation group G2189 FBXO11F-box protein 1180204 FBXW7F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)55294 FCGR2B Fc fragment of IgG, low affinity IIb, receptor for (CD32)2213 FEV FEV protein - (HSRNAFEV)54738 FGFR1fibroblast growth factor receptor 1 2260 FGFR1OP FGFR1 oncogene partner (FOP)11116 FGFR2fibroblast growth factor receptor 2 2263 FGFR3fibroblast growth factor receptor 32261

FH fumarate hydratase2271 FHIT fragile histidine triad gene2272

FIP1L1FIP1 like 1 (S. cerevisiae)81608 FLI1Friend leukemia virus integration 12313 FLJ27352BX648577, FLJ27352 hypothetical LOC145788145788 FLT3fms-related tyrosine kinase 32322 FNBP1formin binding protein 1 (FBP17)23048 FOXL2forkhead box L2668 FOXO1A forkhead box O1A (FKHR)2308 FOXO3A forkhead box O3A2309 FOXP1forkhead box P127086 FSTL3follistatin-like 3 (secreted glycoprotein)10272 FUBP1far upstream element (FUSE) binding protein 18880 FUS fusion, derived from t(12;16) malignant liposarcoma2521 FVT1follicular lymphoma variant translocation 12531 GAS7growth arrest-specific 78522 GATA1GATA binding protein 1 (globin transcription factor 1)2623 GATA2GATA binding protein 22624 GATA3GATA binding protein 32625 GMPS guanine monphosphate synthetase8833 GNA11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)2767 GNAQ guanine nucleotide binding protein (G protein), q polypeptide2776 GNAS guanine nucleotide binding protein (G protein), alpha stimulating activity2778 GOLGA5golgi autoantigen, golgin subfamily a, 5 (PTC5)9950 GOPC golgi associated PDZ and coiled-coil motif containing57120 GPC3glypican 32719 GPHN gephyrin (GPH)10243 GRAF GTPase regulator associated with focal adhesion kinase pp125(FAK)23092

H3F3A H3 histone, family 3A3020 HCMOGT-1sperm antigen HCMOGT-192521 HEAB ATP_GTP binding protein10978 HERPUD1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquit9709 HEY1hairy/enhancer-of-split related with YRPW motif 123462 HIP1huntingtin interacting protein 13092 HIST1H4I histone 1, H4i (H4FM)8294 HLF hepatic leukemia factor3131 HLXB9homeo box HB93110

HMGA1high mobility group AT-hook 13159 HMGA2high mobility group AT-hook 2 (HMGIC)8091 HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B13181 HOOK3hook homolog 384376 HOXA11homeo box A113207 HOXA13homeo box A133209 HOXA9homeo box A93205 HOXC11homeo box C113227 HOXC13homeo box C133229 HOXD11homeo box D113237 HOXD13homeo box D133239 HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog3265 HRPT2hyperparathyroidism 2 3279 HSPCA heat shock 90kDa protein 1, alpha3320 HSPCB heat shock 90kDa protein 1, beta3326 IDH1isocitrate dehydrogenase 1 (NADP+), soluble3417 IDH2socitrate dehydrogenase 2 (NADP+), mitochondrial 3418 IGH@immunoglobulin heavy locus3492 IGK@immunoglobulin kappa locus50802 IGL@immunoglobulin lambda locus3535 IKZF1IKAROS family zinc finger 110320

IL2interleukin 23558

IL21R interleukin 21 receptor50615

IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor)3572

IL7R interleukin 7 receptor146661 IRF4interferon regulatory factor 43662 IRTA1immunoglobulin superfamily receptor translocation associated 183417 ITK IL2-inducible T-cell kinase3702 JAK1Janus kinase 13716 JAK2Janus kinase 2 3717 JAK3Janus kinase 33718 JAZF1juxtaposed with another zinc finger gene 1221895 JUN jun oncogene3725 KDM5A lysine (K)-specific demethylase 5A, JARID1A5927 KDM5C lysine (K)-specific demethylase 5C (JARID1C)8242 KDM6A lysine (K)-specific demethylase 6A, UTX7403 KDR vascular endothelial growth factor receptor 23791 KIAA1549KIAA154957670 KIF5B kinesin family member 5B3799 KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 3815 KLK2kallikrein-related peptidase 23817 KRAS v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog3845 KTN1kinectin 1 (kinesin receptor)3895 LAF4lymphoid nuclear protein related to AF43899 LASP1LIM and SH3 protein 13927 LCK lymphocyte-specific protein tyrosine kinase3932 LCP1lymphocyte cytosolic protein 1 (L-plastin)3936 LCX leukemia-associated protein with a CXXC domain80312 LHFP lipoma HMGIC fusion partner10186 LIFR leukemia inhibitory factor receptor3977 LMO1LIM domain only 1 (rhombotin 1) (RBTN1)4004

LMO2LIM domain only 2 (rhombotin-like 1) (RBTN2)4005 LPP LIM domain containing preferred translocation partner in lipoma4026 LRIG3leucine-rich repeats and immunoglobulin-like domains 3121227 LYL1lymphoblastic leukemia derived sequence 14066 MADH4Homolog of Drosophila Mothers Against Decapentaplegic 4 gene4089 MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog4094 MAFB v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)9935 MALT1mucosa associated lymphoid tissue lymphoma translocation gene 110892 MAML2mastermind-like 2 (Drosophila)84441 MAP2K4mitogen-activated protein kinase kinase 46416 MDM2Mdm2 p53 binding protein homolog4193 MDM4Mdm4 p53 binding protein homolog4194 MDS1myelodysplasia syndrome 14197 MDS2myelodysplastic syndrome 2259283 MECT1mucoepidermoid translocated 194159 MED12mediator complex subunit 129968 MEN1multiple endocrine neoplasia type 1 gene4221 MET met proto-oncogene (hepatocyte growth factor receptor)4233 MITF microphthalmia-associated transcription factor4286 MKL1megakaryoblastic leukemia (translocation) 157591 MLF1myeloid leukemia factor 14291 MLH1 E.coli MutL homolog gene4292 MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosop4297 MLL2myeloid/lymphoid or mixed-lineage leukemia 28085 MLL3myeloid/lymphoid or mixed-lineage leukemia 358508 MLLT1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosop4298 MLLT10myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosop8028 MLLT2 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Droso4299 MLLT3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosop4300 MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosop4301 MLLT6myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosop4302 MLLT7myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosop4303

MN1meningioma (disrupted in balanced translocation) 14330 MPL myeloproliferative leukemia virus oncogene, thrombopoietin receptor4352 MSF MLL septin-like fusion10801 MSH2mutS homolog 2 (E. coli)4436 MSH6mutS homolog 6 (E. coli)2956 MSI2musashi homolog 2 (Drosophila)124540 MSN moesin4478 MTCP1mature T-cell proliferation 14515 MUC1mucin 1, transmembrane4582 MUTYH mutY homolog (E. coli)4595 MYB v-myb myeloblastosis viral oncogene homolog4602 MYC v-myc myelocytomatosis viral oncogene homolog (avian)4609 MYCL1v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma de4610 MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived4613 MYD88myeloid differentiation primary response gene (88)4615 MYH11myosin, heavy polypeptide 11, smooth muscle4629 MYH9myosin, heavy polypeptide 9, non-muscle4627 MYST4MYST histone acetyltransferase (monocytic leukemia) 4 (MORF)23522 NACA nascent-polypeptide-associated complex alpha polypeptide4666

NBS1Nijmegen breakage syndrome 1 (nibrin)4683 NCOA1nuclear receptor coactivator 18648 NCOA2nuclear receptor coactivator 2 (TIF2)10499 NCOA4nuclear receptor coactivator 4 - PTC3 (ELE1)8031 NDRG1N-myc downstream regulated 110397 NF1neurofibromatosis type 1 gene4763

NF2neurofibromatosis type 2 gene4771 NFE2L2nuclear factor (erythroid-derived 2)-like 2 (NRF2)4780 NFIB nuclear factor I/B4781 NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p44791 NIN ninein (GSK3B interacting protein)51199 NKX2-1NK2 homeobox 17080 NONO non-POU domain containing, octamer-binding4841 NOTCH1Notch homolog 1, translocation-associated (Drosophila) (TAN1)4851 NOTCH2Notch homolog 24853 NPM1nucleophosmin (nucleolar phosphoprotein B23, numatrin)4869

NR4A3nuclear receptor subfamily 4, group A, member 3 (NOR1)8013 NRAS neuroblastoma RAS viral (v-ras) oncogene homolog4893 NSD1nuclear receptor binding SET domain protein 164324 NTRK1neurotrophic tyrosine kinase, receptor, type 14914 NTRK3neurotrophic tyrosine kinase, receptor, type 34916 NUMA1nuclear mitotic apparatus protein 14926 NUP214nucleoporin 214kDa (CAN)8021 NUP98nucleoporin 98kDa4928 OLIG2oligodendrocyte lineage transcription factor 2 (BHLHB1)10215 OMD osteomodulin4958

P2RY8purinergic receptor P2Y, G-protein coupled, 8286530 PAFAH1B2platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kD5049 PALB2partner and localizer of BRCA279728 PAX3paired box gene 3 5077 PAX5paired box gene 5 (B-cell lineage specific activator protein)5079 PAX7paired box gene 75081 PAX8paired box gene 87849 PBRM1polybromo 155193 PBX1pre-B-cell leukemia transcription factor 15087 PCM1pericentriolar material 1 (PTC4)5108 PCSK7proprotein convertase subtilisin/kexin type 79159 PDE4DIP phosphodiesterase 4D interacting protein (myomegalin)9659 PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v5155 PDGFRA platelet-derived growth factor, alpha-receptor5156 PDGFRB platelet-derived growth factor receptor, beta polypeptide5159 PER1period homolog 1 (Drosophila)5187 PHF6PHD finger protein 684295 PHOX2B paired-like homeobox 2b8929 PICALM phosphatidylinositol binding clathrin assembly protein (CALM)8301

PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide5290

PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)5295 PIM1pim-1 oncogene5292 PLAG1pleiomorphic adenoma gene 15324 PML promyelocytic leukemia5371 PMS1PMS1 postmeiotic segregation increased 1 (S. cerevisiae)5378

PMS2PMS2 postmeiotic segregation increased 2 (S. cerevisiae)5395 PMX1paired mesoderm homeo box 15396 PNUTL1peanut-like 1 (Drosophila)5413 POU2AF1POU domain, class 2, associating factor 1 (OBF1)5450 POU5F1POU domain, class 5, transcription factor 15460 PPARG peroxisome proliferative activated receptor, gamma5468 PPP2R1A protein phosphatase 2, regulatory subunit A, alpha5518 PRCC papillary renal cell carcinoma (translocation-associated)5546 PRDM1PR domain containing 1, with ZNF domain639 PRDM16PR domain containing 1663976 PRF1perforin 1 (pore forming protein)5551 PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specif5573 PRO1073PRO1073 protein (ALPHA) 29005 PSIP2PC4 and SFRS1 interacting protein 2 (LEDGF)11168 PTCH Homolog of Drosophila Patched gene5727 PTEN phosphatase and tensin homolog gene5728 PTPN11protein tyrosine phosphatase, non-receptor type 115781 RAB5EP rabaptin, RAB GTPase binding effector protein 1 (RABPT5)9135 RAD51L1RAD51-like 1 (S. cerevisiae) (RAD51B)5890 RAF1v-raf-1 murine leukemia viral oncogene homolog 15894 RALGDS ral guanine nucleotide dissociation stimulator5900 RANBP17RAN binding protein 1764901 RAP1GDS1RAP1, GTP-GDP dissociation stimulator 15910 RARA retinoic acid receptor, alpha5914

RB1retinoblastoma gene5925 RBM15RNA binding motif protein 1564783 RECQL4RecQ protein-like 49401 REL v-rel reticuloendotheliosis viral oncogene homolog (avian)5966 RET ret proto-oncogene5979 ROS1v-ros UR2 sarcoma virus oncogene homolog 1 (avian)6098 RPL22ribosomal protein L22 (EAP)6146 RPN1ribophorin I6184 RUNDC2A RUN domain containing 2A84127 RUNX1 runt-related transcription factor 1 (AML1)861 RUNXBP2runt-related transcription factor binding protein 2 (MOZ/ZNF220)7994 SBDS Shwachman-Bodian-Diamond syndrome protein51119 SDC4syndecan 46385 SDH5chromosome 11 open reading frame 7954949 SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)6390 SDHC succinate dehydrogenase complex, subunit C, integral membrane prote6391 SDHD succinate dehydrogenase complex, subunit D, integral membrane prote6392 SEPT6septin 623157 SET SET translocation 6418 SETD2SET domain containing 229072

SF3B1splicing factor 3b, subunit 1, 155kDa23451 SFPQ splicing factor proline/glutamine rich(polypyrimidine tract binding protein6421 SFRS3splicing factor, arginine/serine-rich 36428

SH3GL1SH3-domain GRB2-like 1 (EEN)6455

SIL TAL1 (SCL) interrupting locus6491 SLC34A2solute carrier family 34 (sodium phosphate), member 210568 SLC45A3solute carrier family 45, member 385414

SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chrom6597 SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chrom6598 SMO smoothened homolog (Drosophila)6608 SOCS1suppressor of cytokine signaling 1 8651 SOX2SRY (sex determining region Y)-box 26657 SRGAP3SLIT-ROBO Rho GTPase activating protein 39901 SRSF2serine/arginine-rich splicing factor 26427 SS18synovial sarcoma translocation, chromosome 186760

SS18L1synovial sarcoma translocation gene on chromosome 18-like 126039 SSH3BP1spectrin SH3 domain binding protein 110006 SSX1synovial sarcoma, X breakpoint 16756 SSX2synovial sarcoma, X breakpoint 26757 SSX4synovial sarcoma, X breakpoint 46759 STK11serine/threonine kinase 11 gene (LKB1)6794 STL Six-twelve leukemia gene7955 SUFU suppressor of fused homolog (Drosophila)51684 SUZ12suppressor of zeste 12 homolog (Drosophila)23512 SYK spleen tyrosine kinase6850 TAF15TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated8148 TAL1T-cell acute lymphocytic leukemia 1 (SCL)6886 TAL2T-cell acute lymphocytic leukemia 26887 TCEA1transcription elongation factor A (SII), 16917 TCF1transcription factor 1, hepatic (HNF1)6927 TCF12transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)6938 TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E16929 TCF7L2transcription factor 7-like 26934 TCL1A T-cell leukemia/lymphoma 1A8115 TCL6T-cell leukemia/lymphoma 627004 TET2tet oncogene family member 254790 TFE3transcription factor binding to IGHM enhancer 37030 TFEB transcription factor EB7942 TFG TRK-fused gene10342 TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)29844 TFRC transferrin receptor (p90, CD71)7037 THRAP3thyroid hormone receptor associated protein 3 (TRAP150)9967

TIF1transcriptional intermediary factor 1 (PTC6,TIF1A)8805 TLX1 T-cell leukemia, homeobox 1 (HOX11)3195 TLX3T-cell leukemia, homeobox 3 (HOX11L2)30012 TMPRSS2transmembrane protease, serine 27113 TNFAIP3tumor necrosis factor, alpha-induced protein 37128 TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus en8764 TNFRSF17tumor necrosis factor receptor superfamily, member 17608 TNFRSF6tumor necrosis factor receptor superfamily, member 6 (FAS)355 TOP1topoisomerase (DNA) I7150

TP53tumor protein p537157 TPM3tropomyosin 37170 TPM4tropomyosin 47171 TPR translocated promoter region 7175 TRA@T cell receptor alpha locus6955 TRB@T cell receptor beta locus6957 TRD@T cell receptor delta locus6964

TRIM27tripartite motif-containing 275987 TRIM33 tripartite motif-containing 33 (PTC7,TIF1G)51592 TRIP11thyroid hormone receptor interactor 119321 TSC1tuberous sclerosis 1 gene7248 TSC2tuberous sclerosis 2 gene7249 TSHR thyroid stimulating hormone receptor7253 TTL tubulin tyrosine ligase150465

U2AF1U2 small nuclear RNA auxiliary factor 17307 USP6ubiquitin specific peptidase 6 (Tre-2 oncogene)9098 VHL von Hippel-Lindau syndrome gene7428

VTI1A vesicle transport through interaction with t-SNAREs homolog 1143187 WAS Wiskott-Aldrich syndrome 7454 WHSC1Wolf-Hirschhorn syndrome candidate 1(MMSET)7468 WHSC1L1Wolf-Hirschhorn syndrome candidate 1-like 1 (NSD3)54904 WIF1WNT inhibitory factor 111197 WRN Werner syndrome (RECQL2)7486

WT1Wilms tumour 1 gene7490 WTX family with sequence similarity 123B (FAM123B)139285 WWTR1WW domain containing transcription regulator 1607392 XPA xeroderma pigmentosum, complementation group A7507 XPC xeroderma pigmentosum, complementation group C7508 XPO1exportin 1 (CRM1 homolog, yeast)7514 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase acti7531 ZNF145zinc finger protein 145 (PLZF)7704 ZNF198zinc finger protein 1987750 ZNF278zinc finger protein 278 (ZSG)23598 ZNF331zinc finger protein 33155422 ZNF384zinc finger protein 384 (CIZ/NMP4)171017 ZNF521zinc finger protein 52125925 ZNF9zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)7555 ZRSR2zinc finger (CCCH type), RNA-binding motif and serine/arginin8233

11q24-q25 yes AML

22q36yes prostate

1515q14yes AML

11q21 yes ALL

33p21yes ALL

55q31 yes ALL

77q21-q22yes papillary thyroid

1414q32.32yes breast, colorectal, ovarian, NSCLC

1919q13.1-q13.2 yes ovarian, pancreatic

1212q24.2yes leiomyoma

22p23 yes yes ALCL, NSCLC, Neuroblastoma

1717q25.3yes ALCL

55q21yes yes colorectal, pancreatic, desmoid, he

1111q23.3 yes AML

44p13 yes NHL

11p35.3yes clear cell ovarian carcinoma, RCC

1212q12yes hepatocellular carcinoma

11q21 yes AML

1717q25yes alveolar soft part sarcoma

2020q11.1yes MDS, CMML

1212q13 yes malignant melanoma of soft parts , angiomatoid fibrous

22q35yes ALCL

1111q22.3 yes yes T-PLL

X Xq21.1yes Pancreatic neuroendocrine tumors, paediatric GBM 33p21.31-p21.2yes uveal melanoma, breast, NSCLC, R

11p22yes MALT

22p13 yes B-CLL

1414q32.1yes T-ALL

1818q21.3 yes NHL, CLL

1919q13 yes CLL

1717q22 yes CLL

33q27 yes NHL, CLL

1212q24.1yes BNHL

11q21yes B-ALL

X Xp11.4yes retinoblastoma, AML, APL(translocation) 2222q11.21 yes CML, ALL, AML

1717p11.2yes

1111q22-q23yes MALT

1515q26.1yes

10 10q22.3 yes

77q34yes melanoma, colorectal, papillary thy

1717q21yes yes ovarian

1313q12yes yes breast, ovarian, pancreatic

99q34yes lethal midline carcinoma of young people

1919p13.1yes lethal midline carcinoma of young people

1717q22yes

1212q22yes BCLL

1515q15yes

1212q14.3yes lipoma

1515q21.1yes prostate

1515q14yes lethal midline carcinoma

1616p13.13yes PMBL, Hodgkin Lymphona,

22p23.3yes NSCLC

11p36.31-p36.23yes epitheliod hemangioendothelioma

1717q25yes prostate

77p22 yes DLBCL

1111p15.5yes ALCL

88q22 yes AML

1616q24yes AML

1616q22 yes AML

1111q23.3yes AML, JMML, MDS

33q13.11yes AML

1919q13.2yes AML

1010q21yes NSCLC

1414q11.2yes leiomyoma

1111q13 yes CLL, B-ALL, breast

1212p13yes NHL,CLL

66p21yes MM

1919q12yes serous ovarian

99p24.2yes PMBL, Hodgkin Lymphona,

99p24yes PMBL, Hodgkin Lymphona,

55q32yes NSCLC

1919q13.2yes DLBCL

1717q23yes DLBCL

1616q22.1 yes yes lobular breast, gastric

1616q22.1 yes aneurysmal bone cysts

1717q12yes serous ovarian

1212q14 yes

77q21-q22yes ALL

99p21 yes yes melanoma, multiple other tumour ty

99p21 yes yes melanoma, multiple other tumour ty

11p32yes glioma, MM

1313q12.3 yes AML

1919q13.1yes AML, MDS

99q33yes MPD, NHL

88q11.2yes salivary adenoma

2222q12.1yes

44q11-q12yes AML

22q31-q32.1 yes extraskeletal myxoid chondrosarcoma

1919q13.2yes oligodendroglioma

1616p13yes PMBL, Hodgkin Lymphona,

1717q11-qter yes ALCL, renal

2222q11.21yes ALCL

22q37.3yes lipoma

1717q21.31-q22yes dermatofibrosarcoma protuberans, aneurysmal bone cy 1010p15yes prostate, glioma

88q22-q23 yes uterine leiomyoma

22q34yes clear cell sarcoma, angiomatoid fibrous histiocytoma

1111p11.2yes myxofibrosarcoma

77q34yes fibromyxoid sarcoma

1616p13.3 yes ALL, AML, DLBCL, B-NHL

X,Y Xp22.3; Yp11.3yes B-ALL, Downs associated ALL

1515q26.1yes salivary gland mucoepidermoid

33p22-p21.3 yes colorectal, cvarian, hepatoblastoma, others, pleomorph

1616q12-q13 yes yes cylindroma

1010q21yes papillary thyroid, CML

66p21.3yes Pancreatic neuroendocrine tumors. Paediatric GBM

1111p12yes

1212q13.1-q13.2 yes liposarcoma

1111q22-q23 yes AML*

1717q21yes prostate

1111q23.3yes B-NHL

66p23yes AML

1414q32.13yes yes sex cord-stromal tumour, TGCT, em

1919p13.2yes ETP ALL

22p23yes AML

44q35yes soft tissue sarcoma

55q34yes lipoma

66q24.1yes ETP ALL

77p12.3-p12.1 yes yes glioma, NSCLC

33q27.3yes NHL

X Xq26yes AML

11q32yes prostate

1212p13.3yes papillary thyroid

1919p13.1yes AL

77q11.23yes B-ALL

22p21yes NSCLC

2222q13 yes colorectal, breast, pancreatic, AML, ALL, DLBCL

11p32 yes ALL

1717q21.1 yes breast, ovarian, other tumour types, NSCLC, gastric

1919q13.2-q13.3yes

22q21yes

1616p13.3-p13.13yes

1313q33yes

2121q22.3yes Ewing sarcoma, prostate, AML

7 7p22yes Ewing sarcoma, prostate

1717q21yes Ewing sarcoma, Prostate carcinoma

33q28 yes Prostate

1212p13 yes congenital fibrosarcoma, multiple le

33q26 yes AML, CML

2222q12 yes Ewing sarcoma, desmoplastic sma

88q24.11-q24.13 yes

1111p12-p11yes

77q35-q36yes DLBCL

66q25.3yes NSCLC

55q31 yes AML, AEL

1010q23.2yes edometrial stromal sarcoma

1010q22.3yes edometrial stromal sarcoma

11p12yes MM

1616q24.3yes

99q22.3yes

33p26yes

66p21-p22yes

1111p15yes

99p13yes

22p16.3yes DLBCL

44q31.3yes colorectal, endometrial, T-ALL

11q23yes ALL

22q36yes Ewing sarcoma

88p11.2-p11.1 yes MPD, NHL

66q27yes MPD, NHL

1010q26 yes gastric. NSCLC, endometrial

44p16.3 yes bladder, MM, T-cell lymphoma

11q42.1 yes

33p14.2yes pleomorphic salivary gland adenoma

44q12yes idiopathic hypereosinophilic syndrome

1111q24 yes Ewing sarcoma

1515q21.3yes PMBL, Hodgkin Lymphona,

1313q12 yes AML, ALL

99q23yes AML

33q23yes granulosa-cell tumour of the ovary

1313q14.1 yes alveolar rhabdomyosarcomas

66q21 yes AL

33p14.1yes ALL

1919p13yes B-CLL

11p13.1yes oligodendroglioma

1616p11.2 yes liposarcoma, AML, Ewing sarcoma,

1818q21.3yes B-NHL

1717p yes AML*

X Xp11.23 yes megakaryoblastic leukemia of Downs Syndrome 33q21.3 yes AML(CML blast transformation)

1010p15yes breast

33q24 yes AML

1919p13.3yes uveal melanoma

99q21yes uveal melanoma

2020q13.2 yes pituitary adenoma

1414q yes papillary thyroid

66q21yes glioblastoma

X Xq26.1yes

1414q24 yes AL

55q31 yes AML, MDS

11q42.12yes glioma

1717p11.2yes JMML

1111q12yes AML

1616q12.2-q13yes prostate

88q21yes mesenchymal chondrosarcoma

77q11.23yes CMML

66p21.3 yes NHL

1717q22yes ALL

77q36yes AML

66p21yes microfollicular thyroid adenoma, various benign mesen

1212q15 yes lipoma, leiomyoma, pleiomorphic salivary gland adenom

77p15yes prostate

88p11.21yes papillary thyroid

77p15-p14.2yes CML

77p15-p14.2yes AML

77p15-p14.2 yes AML*

1212q13.3yes AML

1212q13.3yes AML

22q31-q32yes AML

22q31-q32 yes AML*

1111p15.5 yes yes infrequent sarcomas, rare other typ

11q21-q31yes yes parathyroid adenoma

1414q32.31yes NHL

66p12yes NHL

22q33.3yes gliobastoma

1515q26.1yes GBM

1414q32.33yes MM, Burkitt lymphoma, NHL, CLL, B-ALL, MALT, MLCL

22p12yes Burkitt lymphoma, B-NHL

2222q11.1-q11.2yes Burkitt lymphoma

77p12.2yes ALL, DLBCL

44q26-q27yes intestinal T-cell lymphoma

1616p11 yes NHL

55q11yes hepatocellular ca

55p13yes ALL, ETP ALL

66p25-p23yes MM

11q21yes B-NHL

55q31-q32yes peripheral T-cell lymphoma

11p32.3-p31.3yes ALL

99p24 yes ALL, AML, MPD, CML

1919p13.1yes acute megakaryocytic leukemia, ETP ALL

77p15.2-p15.1yes endometrial stromal tumours

11p32-p31yes sarcoma

1212p11yes AML

X Xp11.22-p11.21yes clear cell renal carcinoma

X Xp11.2yes renal, oesophageal SCC, MM

44q11-q12yes NSCLC, angiosarcoma

77q34yes pilocytic astrocytoma

1010p11.22yes NSCLC

44q12yes yes GIST, AML, TGCT, mastocytosis, m

1919q13.41yes prostate

1212p12.1 yes pancreatic, colorectal, lung, thyroid, AML, others

1414q22.1yes papillary thryoid

22q11.2-q12 yes ALL, T-ALL

1717q11-q21.3yes AML

11p35-p34.3 yes T-ALL

13 13q14.1-q14.3 yes NHL

1010q21yes AML

1313q12yes lipoma

55p13-p12yes salivary adenoma

1111p15 yes yes T-ALL, neuroblastoma

1111p13yes T-ALL

33q28 yes lipoma, leukemia

1212q14.1yes NSCLC

1919p13.2-p13.1yes T-ALL

1818q21.1 yes yes colorectal, pancreatic, small intestin

1616q22-q23yes MM

2020q11.2-q13.1yes MM

1818q21yes MALT

1111q22-q23yes salivary gland mucoepidermoid

1717p11.2 yes pancreatic, breast, colorectal

1212q15 yes sarcoma, glioma, colorectal, other

11q32yes GBM, bladder, retinoblastoma

3 3q26 yes MDS, AML

11p36yes MDS

1919p13yes salivary gland mucoepidermoid

X Xq13yes uterine leiomyoma

1111q13 yes yes parathyroid tumors, Pancreatic neu

77q31yes papillary renal, head-neck squamou

33p14.1yes melanoma

2222q13yes acute megakaryocytic leukemia

33q25.1yes AML

33p21.3 yes yes colorectal, endometrial, ovarian, CN

1111q23 yes AML, ALL

1212q12-q14yes medulloblastoma, renal

77q36.1yes medulloblastoma

1919p13.3 yes AL

1010p12 yes AL

44q21 yes AL

99p22 yes ALL

66q27 yes AL

1717q21yes AL

X Xq13.1 yes AL

2222q13yes AML, meningioma

1p34yes yes MPD

17 17q25yes AML*

22p22-p21yes yes colorectal, endometrial, ovarian

22p16yes yes colorectal

1717q23.2yes CML

X Xq11.2-q12yes ALCL

X Xq28yes T cell prolymphocytic leukemia

11q21yes B-NHL

11p34.3-1p32.1 yes

66q22-23yes adenoid cystic carcinoma

88q24.12-q24.13 yes Burkitt lymphoma, amplified in other cancers, B-CLL

11p34.3 yes small cell lung

22p24.1 yes neuroblastoma

33p22yes ABC-DLBCL

1616p13.13-p13.12 yes AML

2222q13.1yes ALCL

1010q22 yes AML

1212q23-q24.1 yes NHL

22p23yes alveolar rhadomyosarcoma

88q13.1yes AML, Chondrosarcoma

1010q11.2 yes papillary thyroid

88q24.3yes prostate

1717q12yes yes neurofibroma, glioma

2222q12.2 yes yes meningioma, acoustic neuroma, re

22q31yes NSCLC, HNSCC

99p24.1yes adenoid cystic carcinoma, lipoma

1010q24yes B-NHL

1414q24yes MPD

1414q13yes NSCLC

X Xq13.1yes papillary renal cancer

9 9q34.3 yes T-ALL

11p13-p11yes marginal zone lymphoma, DLBCL

55q35yes NHL, APL, AML

99q22 yes extraskeletal myxoid chondrosarcoma

11p13.2 yes melanoma, MM, AML, thyroid

55q35 yes AML

11q21-q22 yes papillary thyroid

1515q25 yes congenital fibrosarcoma, Secretory breast

1111q13yes APL

99q34.1yes AML, T-ALL

1111p15 yes AML

2121q22.11yes T-ALL

99q22.31yes aneurysmal bone cysts

X,Y Xp22.3; Yp11.3yes B-ALL, Downs associated ALL

1111q23yes MLCLS

1616p12.1yes

22q35yes alveolar rhabdomyosarcoma

99p13yes NHL, ALL, B-ALL

11p36.2-p36.12 yes alveolar rhabdomyosarcoma

22q12-q14 yes follicular thyroid

33p21yes clear cell renal carcinoma, breast

11q23 yes pre B-ALL, myoepithelioma

88p22-p21.3 yes papillary thyroid, CML, MPD

1111q23.3yes MLCLS

11q12yes MPD

2222q12.3-q13.1yes DFSP

44q11-q13yes GIST, idiopathic hypereosinophilic syndrome, paediatric

55q31-q32 yes MPD, AML, CMML, CML

1717p13.1-17p12yes AML, CMML

X Xq26.3yes ETP ALL

44p12yes yes neuroblastoma

1111q14 yes TALL, AML,

33q26.3yes colorectal, gastric, gliobastoma, breast

55q13.1yes gliobastoma, ovarian, colorectal

66p21.2 yes NHL

88q12yes salivary adenoma

1515q22 yes APL, ALL

22q31-q33 yes

11q24 yes AML

2222q11.2 yes AML

1111q23.1 yes NHL

66p21.31yes sarcoma

3 3p25 yes follicular thyroid

1919q13.41yes clear cell ovarian carcinoma

11q21.1yes papillary renal

66q21yes DLBCL

11p36.23-p33yes MDS, AML

1010q22yes

1717q23-q24yes yes papillary thyroid

1111q31.1yes renal cell carcinoma (childhood epithelioid)

99p22.2yes AML

99q22.3yes yes skin basal cell , medulloblastoma

1010q23.3yes yes glioma, prostate, endometrial

1212q24.1yes JMML, AML, MDS

1717p13yes CMML

1414q23-q24.2yes lipoma, uterine leiomyoma

33p25yes pilocytic astrocytoma

99q34.3yes PMBL, Hodgkin Lymphona,

55q34yes ALL

44q21-q25yes T-ALL

17 17q12 yes APL

1313q14yes yes retinoblastoma, sarcoma, breast, sm

11p13yes acute megakaryocytic leukemia

88q24.3yes

2 2p13-p12yes Hodgkin Lymphoma

1010q11.2yes yes medullary thyroid, papillary thyroid

66q22yes glioblastoma, NSCLC

11p36.31yes AML, CML

33q21.3-q25.2yes AML

1616p13.13yes PMBL, Hodgkin Lymphona,

2121q22.3 yes AML, preB- ALL, T-ALL

88p11yes AML

77q11yes

2020q12yes NSCLC

1111q12.2yes

11p36.1-p35 yes

11q21 yes

1111q23 yes

X Xq24yes AML

99q34yes AML

33p21.31yes clear cell renal carcinoma

22q33.1yes myelodysplastic syndrome

11p34.3yes papillary renal cell

66p21yes follicular lymphoma

19 19p13.3 yes AL

11p32yes T-ALL

44p15.2yes NSCLC

11q32yes prostate

1919p13.2yes NSCLC

2222q11 yes yes malignant rhabdoid

77q31-q32 yes skin basal cell

1616p13.13yes Hodgkin Lymphoma, PMBL

33q26.3-q27yes NSCLC, oesophageal squamous carcinoma

33p25.3yes pilocytic astrocytoma

1717q25yes MDS, CLL

1818q11.2yes synovial sarcoma

2020q13.3yes synovial sarcoma

1010p11.2 yes AML

X Xp11.23-p11.22yes synovial sarcoma

X Xp11.23-p11.22yes synovial sarcoma

X Xp11.23yes synovial sarcoma

1919p13.3yes yes NSCLC, pancreatic

66q23 yes B-ALL

1010q24.32yes yes medulloblastoma

1717q11.2yes endometrial stromal tumours

99q22yes MDS, peripheral T-cell lymphoma

1717q11.1-q11.2yes extraskeletal myxoid chondrosarcomas, ALL

11p32 yes lymphoblastic leukemia/biphasic

99q31yes T-ALL

88q11.2yes salivary adenoma

1212q24.2yes yes hepatic adenoma, hepatocellular ca

1515q21yes extraskeletal myxoid chondrosarcoma

1919p13.3 yes pre B-ALL

1010q25.3yes colorectal

1414q32.1yes T-CLL

1414q32.1yes T-ALL

44q24yes MDS

X Xp11.22yes papillary renal, alveolar soft part sarcoma, renal 66p21yes renal (childhood epithelioid)

33q11-q12yes papillary thyroid, ALCL, NSCLC

1919q13yes pre-B ALL

33q29 yes NHL

11p34.3yes aneurysmal bone cysts

77q32-q34 yes APL

1010q24yes T-ALL

55q35.1yes T-ALL

2121q22.3yes prostate

66q23yes marginal zone B-cell lymphomas, H

11p36.32yes follicular lymphoma

1616p13.1yes intestinal T-cell lymphoma

1010q24.1yes TGCT, nasal NK/T lymphoma, skin squamous cell ca -b

2020q12-q13.1 yes AML*

1717p13yes yes breast, colorectal, lung, sarcoma, a

11q22-q23 yes papillary thyroid, ALCL, NSCLC

1919p13.1yes ALCL

11q25 yes papillary thyroid

1414q11.2yes T-ALL

77q35 yes T-ALL

1414q11yes T-cell leukemia

66p22yes papillary thyroid

11p13yes papillary thyroid

1414q31-q32 yes AML

99q34 yes

1616p13.3 yes

1414q31 yes yes toxic thyroid adenoma

22q13yes ALL

2121q22.3yes CLL, MDS

1717p13yes aneurysmal bone cysts

33p25yes yes renal, hemangioma, pheochromocy

1010q25.2yes colorectal

X Xp11.23-p11.22

44p16.3yes MM

88p12 yes AML

1212q14.3yes pleomorphic salivary gland adenoma

88p12-p11.2yes

1111p13yes yes Wilms, desmoplastic small round c

X Xq11.1yes Wilms tumour

33q23-q24yes epitheliod hemangioendothelioma

99q22.3yes

33p25yes

22p15yes-'CLL

1717p13.3yes edometrial stromal sarcoma

1111q23.1 yes APL

1313q11-q12yes MPD, NHL

2222q12-q14 yes Ewing sarcoma

1919q13.3-q13.4yes follicular thyroid adenoma

1212p13 yes ALL

1818q11.2yes ALL

33q21yes aneurysmal bone cysts

X Xp22.1yes MDS, CLL