Inhibitors, Agonists, Screening Libraries
https://www.sodocs.net/doc/fa3313363.html, Data Sheet
BIOLOGICAL ACTIVITY:
USP7–IN–1 is a novel selective and reversible inhibitor of USP7 with IC50 of 33 uM; less or no inhibition on USP5, USP8, Uch–L1,Uch–L3 and Caspase(IC50>200 uM); HCT116 cell viability GI50 is 67 uM.
IC50 value: 33 uM
Target: USP7 selective inhibitor
Preparation of quinazoline derivatives useful as selective and reversible inhibitors of USP7
By Colland, Frederic; Gourdel, Marie–Edith
From PCT Int. Appl. (2013), WO 2013030218 A1 20130307.
Product Name:
USP7–IN–1Cat. No.:
HY-16709CAS No.:
1381291-36-6Molecular Formula:
C 23H 24ClN 3O 3Molecular Weight:
425.91Target:
Deubiquitinase Pathway:
Cell Cycle/DNA Damage Solubility:
DMSO: ≥ 40 mg/mL
Caution: Product has not been fully validated for medical applications. For research use only.
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https://www.sodocs.net/doc/fa3313363.html,