搜档网
当前位置:搜档网 › 神经再生- 周围神经损伤

神经再生- 周围神经损伤

神经再生- 周围神经损伤

Transplantation of Nogo-66 receptor gene-silenced cells in a poly(D,L-lactic-co-glycolic acid) scaffold for the treatment of spinal cord injury

研究亮点:

(1) Transplantation of Nogo-66 receptor gene-silenced bone marrow mesenchymal stem cells and Schwann cells, combined with a

poly(D,L-lactide-co-glycolic acid) scaffold, can significantly enhance axonal regeneration of spinal cord neurons and improve motor function of the extremities in rats following spinal cord injury.

(2) Combined transplantation of bone marrow mesenchymal stem cells and Schwann cells, with Nogo-66 receptor gene silencing, can reduce glial scar formation and promote axonal growth of nerve cells, and rapidly repair the injured nerves.

1 应用NgR基因沉默骨髓间充质干细胞和许旺细胞,再联合聚乳酸-乙醇酸支架移植能够明显促进脊髓损伤大鼠的脊髓神经元轴突再生,并改善肢体的功能。

2 骨髓间充质干细胞和许旺细胞联合移植,在NgR基因沉默的条件下,借助于生物支架技术,可减少胶质瘢痕,形成构筑重建,促进神经细胞的轴性生长,使损伤的神经得以迅速修复。

Neural Regeneration Research

《中国神经再生研究(英文版)》

相关主题