投稿coverletter写法

Case 1

Dear Editor,

We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience.

GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease.

Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am Sincerely yours,

case2

Dear Editor,

We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron.

We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release.

某杂志给出的标准Sample Cover Letter

Case 3

Sample Cover Letter

Dear Editor of the :

Enclosed is a paper, entitled "Mobile Agents for Network Management." Please accept it as a candidate for publication in the . Below are our responses to your submission requirements.

1. Title and the central theme of the article.

Paper title: "Mobile Agents for Network Management." This study reviews the concepts of mobile agents and distributed network management system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.

2. Which subject/theme of the Journal the material fits

New enabling technologies (if no matching subject/theme, enter 'Subject highly related to but not listed by )

3. Why the material is important in its field and why the material should be published in ?

The necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management system has become increasingly important today's distributed environment. However, the conventional centralized architecture, which routinely requests the status information of local units by the central server, is not sufficient to manage the growing requests. Recently, a new framework that uses mobile

agent technology to assist the distributed management has emerged. The mobile agent reduces network traffic, distributes management tasks, and improves operational performance. Given today's bandwidth demand over the Internet, it is important for the readers

to understand this technology and its benefits. This study gives a real-life example of how to use mobile agents for distributed network management. It is the first in the literature that reports the analysis of network performance based on an operational prototype of mobile agent-based distributed

network. We strongly believe the contribution of this study warrants its publication in the .

4. Names, addresses, and email addresses of four expert referees.

Prof. Dr. William Gates

Chair Professor of Information Technology

321 Johnson Hall

Premier University Lancaster, NY 00012-6666, USA

phone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail: wgates@https://www.sodocs.net/doc/1513786969.html,

Expertise: published a related paper ("TCP/IP and OSI: Four Strategies for Interconnection") in CACM, 38(3), pp. 188-198.

Relationship: I met Dr. Gate only once at a conference in 1999. I didn't know him personally. Assoc Prof. Dr. John Adams

Director of Network Research Center

College of Business Australian University

123, Harbor Drive Sydney,

Australia 56789

phone: +61-8-8888-8888 - fax: +61-8-8888-8886

e-mail: jadams@https://www.sodocs.net/doc/1513786969.html,.au

Expertise: published a related paper ("Creating Mobile Agents") in IEEE TOSE, 18(8), pp. 88-98. Relationship: None. I have never met Dr. Adams.

Assoc Prof. Dr. Chia-Ho Chen

Chair of MIS Department

College of Management

Open University

888, Putong Road

Keelung, Taiwan 100

phone: +886-2-8888-8888 - fax: +886-2-8888-8886

e-mail: chchen@https://www.sodocs.net/doc/1513786969.html,.tw

Expertise: published a related paper ("Network Management for E-Commerce") in IJ Electronic Business, 1(4), pp. 18-28.

Relationship: Former professor, dissertation chairman.

Mr. Frank Young

Partner, ABC Consulting

888, Seashore Highway

Won Kok, Kowloon

Hong Kong

phone: +852-8888-8888 - fax: +852-8888-8886

e-mail: fyoung@https://www.sodocs.net/doc/1513786969.html,

Expertise: Mr. Young provides consulting services extensively to his clients regarding network management practices.

Relationship: I have worked with Mr. Young in several consulting projects in the past three years. Finally, this paper is our original unpublished work and it has not been submitted to any other journal for reviews.

Sincerely,

Johnny Smith

Dear ***

We are submitting our manuscript entitled “~~~~”, ~~ pages with ~~ figures, for your kind consideration of its suitability for publication in ~~~~. The manuscript has not been previously published, is not currently submitted for review to any other journal, and will not be submitted elsewhere before a decision is made by this journal. In addition, a justification for the publication in Journal of Power Sources is enclosed.

A paragraph explaining why our manuscript is appropriate for ~~~

（此处讲你工作的优点和创新点在哪里，吹一吹）. Therefore, we respectfully submit this paper and hope it may first be published for ~~~

Sincerely yours,

Dear Mr. **

1. The work described has not been submitted elsewhere for publication, in whole or in part, and all the authors listed have approved the manuscript that is enclosed.

2. I have read and have abided by the statement of ethical standards for manuscripts submitted to Neuroscience.

kind regards.

Your sincerely,

通讯作者

常用模板（2）

Dear Dr. 主编name:

We submit our manuscript entitled " 文章title" to 杂志名for publication.

接着简单介绍你文章的主要创新点和意义，不易过多，但要突出新意和关键点。

All authors have seen the manuscript and approved to submit to your journal.

Thank you very much for your attention and consideration.

Sincerely yours,

通讯作者

常用模板（3）

Dear Dr. 主编name:

We submit our manuscript entitled " 文章title" to 杂志名for publication.

接着简单介绍你文章的主要创新点和意义，不易过多，但要突出新意和关键点。

All authors have seen the manuscript and approved to submit to your journal.

Thank you very much for your attention and consideration.

Sincerely yours,

通讯作者

常用模板（4）

Dr. ***

Editor-in-Chief, ***

(add address) January 22, 2010

Dear Dr. **,

Enclosed herewith please find 3 copies of a MS by: ‘***. *** and ***’ entitled: “**********”, which we wo uld like to submit for publication in the ‘******'.

Looking forward to your decision,

With kind personal regards,

Sincerely yours,

*****

Professor of ***

常用模板（5）

Dear Prof. xx:

This is a manuscript by**and **entitled “.......”. It is submitted to be consid ered for publication as a “...” in your journal. This paper is new. Neither the entire paper nor any part of its content has been published or has been accepted elsewhere. It is not being submitted to any other journal. We believe the paper may be of particular interest to the readers of your journal as it ........ Correspondence should be addressed to **at the following address, phone and fax number, and email address:

...

Thanks very much for your attention to our paper.

Sincerely yours,

CoverLetter英文简历书写 模板

CoverLetter英文简历书写模板 Writing the Cover Letter Writing the Cover Letter What is A Cover Letter? What is A Cover Letter Writing: Invitation to find out Persuasive Writing: Invitation to find out more about you and land Targeted Response to A Job Description and/or a Particular organization and/or a Particular organization—— THESE QUESTIONS: Can you do the job? Can you do the job? Will you do the job? Will you do the job? Will you fit in? Will you fit Cover Letter Four Steps for Cover Letter Writing From https://www.sodocs.net/doc/1513786969.html, Writing From https://www.sodocs.net/doc/1513786969.html, 1. 1. Conduct Research on The Conduct Research on The Organization Organization 2. 2. Deconstruct the job or internship Deconstruct the job or internship description description 3. 3. Consolidate and prioritize the key Consolidate and prioritize the key requirements you have extracted requirements you have extracted 4. 4. Plug yourself into the organizational Plug yourself into the organizational and job requirements and job requirements The Job Description The Job Description Climate and Energy Program (CEP) Climate and Energy Program (CEP) Internship, WRI Internship, WRI Position Summary WRI's Climate and Energy Program (CEP) seeks a WRI's Climate and Energy Program (CEP) seeks a motivated, well motivated, well--organized, and detail organized, and detail--oriented oriented intern to support our climate change and energy intern to support our climate change and energy policy work. The successful candidate will support policy work. The successful candidate will support CEP staff in a wide variety of activities including CEP staff in a wide variety of activities including publications management, event coordination, publications management, event coordination, database management, financial management, database management, financial management, and other tasks related to general program and other tasks related to general program administration. administration. 1. Research: 1. Transport Climate, Energy and Transport Division Projects: Division Projects: ––COP COP--15: Countdown to Copenhagen 15: Countdown to Copenhagen ––U.S. Federal Climate Policy U.S. Federal Climate Policy ––International & U.S. Action International & U.S. Action ––Business & Markets Business & Markets ––Technology & Green Power Technology & Green Power ––Energy Security & Climate Change Energy Security & Climate Change ––Information & Analysis Tools Information & Analysis Tools 1. Research: 1. Research: World Resources Institute --18, 2009, the world will 18, 2009, the world will convene in Copenhagen, Denmark to create convene in Copenhagen, Denmark to create a new global climate agreement to reduce a new global climate agreement to reduce greenhouse gas emissions at the greenhouse gas emissions at the United United Nations Climate Change Conference Nations Climate Change Conference (COP (COP-- experts have been actively involved in WRI’s experts have been actively involved in the negotiations leading up to the negotiations leading up to COP COP--15 15 and and are analyzing various dimensions of a new are analyzing various dimensions of a new agreement, among them: Vulnerability and agreement, among them: Vulnerability and Adaptation; Adaptation; Forestry and Reduced Emissions Forestry and Reduced Emissions for Degradation and Deforestation (REDD); for Degradation and Deforestation (REDD); Technology and Technology Transfer; Technology

英文论文投稿信Coverletter模板

英文论文投稿信Cover letter模板 qiusuo BY - 2006-1-17 8:59:00 Dear Editor, We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience. GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease. Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am Sincerely yours, case2 Dear Editor, We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron. We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a

怎样写好国外期刊修改稿的Cover_Letter

Cover Letter是一篇文章的外衣,对国外投稿能否成功很关键,一般投稿时的Cover Letter并不是很重要,只要说明你稿件的研究方向及创新点,并声明没有在其他期刊发表过.最难写的就是Revised Manuscript中的Cover Letter,这将关系到是否录用你的稿件,或要进一步审稿.国外专家讲求的是精益求精,老外们对文章都很严谨的,一个单词哪怕是一个介词的使用都是很有考究的,因此会提出很多似乎对文章无关紧要的修改意见,但是这你要给予充分的重视.通过国外发表几篇文章后,开始一直失败,但是我没有放弃,通过总结现在将一些经验和大家分享,以免大家走很多不必要的弯路. 为了更好理解,我用我发的一篇文章作为例子来说明: 这里是期刊审稿人的修改意见: Dear *****, The review of your manuscript, Thermal Decomposition and Kinetics Studies on 1, 4-dinitropiperazine (DNP), submitted to Journal of Hazardous Materials has been completed. The reviewers recommend the need for minor revisions. Please revise your manuscript according to the reviewers' comments attached, and re-submit to me your revised version of the manuscript including an itemized response to each reviewer's comments. Please submit your revised submission before Jul 11, 2007. I will then begin the re-review process. Please note that revised manuscripts will be sent for review because revising a manuscript does not automatically mean it will be accepted for publication. For your guidance, reviewers' comments are appended below. On your Main Menu page is a folder entitled "Submissions Needing Revision". You will find your submission record there. Please ensure that the article conforms to the format of the Journal. In particular make sure that all the articles in your references have titles included. The Journal Guide for Authors is available on the Journal homepage

投稿的信件书写方法

一、投稿信 1. Dear Dr. Defendi ML: I am sending a manuscript entitled “” by – which I should like to submit for possible publication in the journal of - . Yours sincerely 2. Dear Dr. A: Enclosed is a manuscript entitled “” by sb, which we are submitting for pub lication in the journal of - . We have chosen this journal because it deals with - . We believe that sth would be of interest to the journal’s readers. 3. Dear Dr. A: Please find enclosed for your review an original research article, “” by sb. All authors have read and approve this version of the article, and due care has been taken to ensure the integrity of the work. No part of this paper has published or submitted elsewhere. No conflict of interest exits in the submission of this manuscript, and we have attached to this letter the signed letter granting us permission to use Figure 1 from another source. We appreciate your consideration of our manuscript, and we look forward to receiving comments from the reviewers. 二、询问有无收到稿件 Dear Editors, We dispatched our manuscript to your journal on 3 August 2006 but have not, as yet, receive acknowledgement of their safe arrival. We fear that may have been lost and should be grateful if you would let us know whether or not you have received them. If not, we will send our manuscript again. Thank you in advance for your help. 三、询问论文审查回音 Dear Editors， It is more than 12 weeks since I submitted our manuscript (No: ) for possible publication in your journal. I have not yet received a reply and am wondering whether you have reached a decision. I should appreciated your letting me know what you have decided as soon as possible. 四、关于论文的总体审查意见 1. This is a carefully done study and the findings are of considerable interest. A few minor revision are list below. 2. This is a well-written paper containing interesting results which merit publication. For the benefit of the reader, however, a number of points need clarifying and certain statements require further justification. There are given below. 3. Although these observation are interesting, they are rather limited and do not advance our knowledge of the subject sufficiently to warrant publication in PNAS. We suggest that the authors try submitting their findings to specialist journal such as – 4. Although this paper is good, it would be ever better if some extra data were added. 5. This manuscript is not suitable for publication in the journal of –because the main observation it describe was reported 3 years ago in a reputable journal of - . 6. Please ask someone familiar with English language to help you rewrite this paper. As you will see, I have made some correction at the beginning of the paper where some syntax is not satisfactory. 7. We feel that this potentially interesting study has been marred by an inability to communicate the finding correctly in English and should like to suggest that the authors seek the advice of someone with a

给一个答复审稿人意见的coverletter

给一个答复审稿人意见的coverletter,希望对大家有帮助 Cover letter Manuscript number: BXXXXXK MS Type: Article Title: "XXXX" Correspondence Author: XXX Dear Dr. Fay Riordan: Thank you very much for your attention and the referee’s evaluation and comments on our paper BXXXXK. We have revised the manuscript according to your kind advices and referee’s detailed suggestions. Enclosed please find the responses to the referees. We sincerely hope this manuscript will be finally acceptable to be published on XXX. Thank you very much for all your help and looking forward to hearing from you soon. Best regards Sincerely yours Dr. XXX Please find the following Response to the comments of referees: Response to the referee’s comments Referee A Comment 1: The titania material formed after calcining at 450 oC is not characterized. XRD of these calcined materials should be provided to understand the crystallinity and phase. Response: Thanks for the referee’s kind suggestion. According to his/her advices, X-ray diffractometry spectroscopy (XRD) of the calcined TiO2 film was given in Supporting Information (Figure S1) in this revised version. It illustrated that the hydrothermal synthesized TiO2 materials after calcining at 450 oC is entire anatase, which was confirmed by the X-ray diffractometer with Cu Kα radiation (Rigaku D/ max-2500). Comment 2: The authors must state the mechanical strength of these materials after the removal of PS by calcinations. Response: Thanks for the referee’s suggestion. By a scotch tape peel test, the TiO2 film can’t be stripped from the conducting glass substrate, which indicates that the mechanical strength of as-prepared composite film is strong enough for the fabrication of solar cell devices. The revised details can be found in Line 165-168, page 2. Referee B Comment 1: The microtube structure with the size of 500-800 nm cannot only scatter the visible light in the region of 500-800 nm, but also can scatter more efficiently the visible light in the region below 500 nm, and can scatter near infrared light. This point should be clarified in the main text. Response: Thanks for the referee’s kind advice. Just like what the referee said, the microtube network structure can scatter not only visible light but also near infrared light. We added this point in revised manuscript and the detailed revision can be found in Line 194-205, Page 2-3.

SCI 投稿Cover letter模板大全

SCI 投稿Cover letter模板大全 1. 第一次投稿Cover letter：主要任务是介绍文章主要创新以及声 明没有一稿多投 Dear Editors: We would like to submit the enclosed manuscript entitled “Paper Title”, which we wish to be considered for publication in “Journal Name”. No conflict of interest exits in the submission of this manuscript, and manuscript is approved by all authors for publication. I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed. In this work, we evaluated …… (简要介绍一下论文的创新性). I hope this paper is suitable for “Journal Name”. The following is a list of possible reviewers for your consideration: 1) Name A E-mail: ××××@×××× 2) Name B E-mail: ××××@×××× We deeply appreciate your consideration of our manuscript, and we look forward to receiving comments from the reviewers. If you have any queries, please don’t hesitate to contact me at the address below. Thank you and best regards. Yours sincerely, ××××××Corresponding author: Name: ××× E-mail: ××××@×××× 2. 催稿信：询问稿件处理到声明步骤 Dear Prof. ×××: Sorry for disturbing you. I am not sure if it is the right time to contact you to inquire about the status of my submitted manuscript titled “Paper Title”. (ID: 文章稿号), although the status of “With Editor” has been lasting for more than two months, since submitted to journal three months ago. I am just wondering that my manuscript

分享两篇SCI发表的经历(cover letter、response letter)

分享两篇SCI发表的经历 三年前对于我来说SCI就是天书一样，在我踏进博士的门槛后我以为自己进入了地狱，也纠结也彷徨，整天刷虫友们对于博士、SCI的帖子，我选择了虫友们鼓励的那一部分来激励自己继续前行。我告诉自己坚持就是胜利，当然那是积极的坚持。在好几月之前就有这个想法，今天早上收到第二篇的接收通知后，我便想今天一定要在小木虫上谢谢那些给予我帮助的虫友们。 话不多说，我把自己这两篇投稿的经历与大家共享，希望能给大家带来一点点用处。 第一篇发表在Fitoterapia Cover letter Dear Editor Verotta: We would like to submit the manuscript entitled "××××××题目" by ××××××所有作者姓名which we wish to be considered for publication in Journal of Fitoterapia. All authors have read and approved this version of the article, and due care has been taken to ensure the integrity of the work. Neither the entire paper nor any part of its content has been published or has been accepted elsewhere. It is not being submitted to any other journal. We believe the paper may be of particular interest to the readers of your journal as it is the first time of ××××××研究的精华所在 Thank you very much for your reconsidering our revised manuscript for potential publication in Fitoterapia. We are looking forward to hearing from you soon. Correspondence should be addressed to Jinhui Yu at the following address, phone and fax number, and email address. 地址、学院、学校名称 Phone: + 86×××××× Fax number: + 86571××××××

JMCA投稿模板

Please do not adjust margins Please do not adjust margins Address here. Address here. Address here. ? Footnotes relating to the title and/or authors should appear here. Electronic Supplementary Information (ESI) available: [details of any supplementary information available should be included here]. See DOI: 10.1039/x0xx00000x Received 00th January 20xx, Accepted 00th January 20xx DOI: 10.1039/x0xx00000x Title Author Full Name,*a Author Full Name b and Author Full Name c Abstract text goes here. The abstract should be a single paragraph that summarises the content of the article A Headings are the primary heading type e.g. Introduction, Results and discussion, Experimental B Headings should always be subordinate to A headings e.g. Synthetic procedures, Materials and methods, Crystallography. C headings should always be subordinate to B headings e.g. General procedure for synthesis of compound X. The main paragraph text follows directly on here. The main text of the article should appear here with headings as appropriate. Conclusions The conclusions section should come in this section at the end of the article, before the acknowledgements. Conflicts of interest In accordance with our policy on Conflicts of interest please ensure that a conflicts of interest statement is included in your manuscript here. Please note that this statement is required for all submitted manuscripts. If no conflicts exist, please state that “There are no conflicts to declare”. Acknowledgements The acknowledgements come at the end of an article after the conclusions and before the notes and references. Notes and references ? Footnotes relating to the main text should appear here. These might include comments relevant to but not central to the matter under discussion, limited experimental and spectral data, and crystallographic data. § §§ etc. Citations should appear here in the format A. Name, B. Name and C. Name, Journal Title , 2000, 35, 3523; A. Name, B. Name and C. Name, Journal Title , 2000, 35, 3523. …

投稿coverletter写法

Case 1 Dear Editor, We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience. GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease. Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am Sincerely yours, case2 Dear Editor, We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron. We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release. 某杂志给出的标准Sample Cover Letter Case 3 Sample Cover Letter Dear Editor of the : Enclosed is a paper, entitled "Mobile Agents for Network Management." Please accept it as a candidate for publication in the . Below are our responses to your submission requirements. 1. Title and the central theme of the article. Paper title: "Mobile Agents for Network Management." This study reviews the concepts of mobile agents and distributed network management system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.