_-_-Borneol_DataSheet_MedChemExpress

Inhibitors, Agonists, Screening Libraries

https://www.sodocs.net/doc/2a1614201.html, Data Sheet

BIOLOGICAL ACTIVITY:

(–)–Borneol has a highly efficacious positive modulating action at GABA receptor with an EC 50 of 237 μM.

IC50 & Target: EC50: 237 μM (GABA receptor)[1]

In Vitro: (–)–Borneol is an enantiomer of (+)–Borneol. (+)–Borneol is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC 50 of 248 μM. At high concentrations (>1.5 mM),

(–)–Borneol directly activates GABAA receptors producing 84% of the maximal GABA response indicative of a weak partial agonist action. (–)–Borneol produces dose–dependent positive modulation of the Cl – conductance generated by extremely low dose GABA at

α1β2γ2L GABAA receptors [1].References:

[1]. IGranger RE, et al. (+)– And (–)–borneol: efficacious positive modulators of GABA action at human recombinantalpha1beta2gamma2L GABA(A) receptors.Biochem Pharmacol. 2005 Apr 1;69(7):1101–11.

Product Name:

(–)–Borneol Cat. No.:

HY-N1368B CAS No.:

464-45-9Molecular Formula:

C10H18O Molecular Weight:

154.25Target:

GABA Receptor Pathway:

Membrane Transporter/Ion Channel; Neuronal Signaling Solubility:

DMSO

Caution: Product has not been fully validated for medical applications. For research use only.

Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@https://www.sodocs.net/doc/2a1614201.html, Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA

https://www.sodocs.net/doc/2a1614201.html,